33780-98-2Relevant academic research and scientific papers
Novel Synthesis of α-Substituted Acrylic Acids
Serota, S.,Simon, J. R.,Murray, E. B.,Linfield, W. M.
, p. 4147 - 4151 (2007/10/02)
A facile three-step procedure has been developed for the synthesis of α-substituted acrylic acids.In the first step, a carboxylic acid having no α-substituents is condensed with 2-amino-2-methylpropanol (AMP) to form the corresponding oxazoline.The oxazoline reacts readily with paraformaldehyde to give an intermediate mixture of mono- and dimethylol derivatives which upon heating forms the α-methylene derivatives of the oxazoline.The latter, upon acid hydrolysis, yields the α-substituted acrylic acid generally in an overall yield of above 70percent and the acids are usually at least 95percent pure.
Alkenylglycidic acid derivatives
-
, (2008/06/13)
Glycidic acid derivatives substituted in the 2-position with a long chain alkenyl of from 11 to 16 carbons having hypoglycemic activity.
Dibromoalkylglycidic acid derivatives
-
, (2008/06/13)
Glycidic acid derivatives substituted in the 2-position with a long chain dibromoalkyl of from 11 to 16 carbons having hypoglycemic activity.
