337903-25-0

Upstream product

• 643-79-8 o-phthalic dicarboxaldehyde 
• 337903-22-7 3,5-O-(2-formylbenzylidene)-1,2-O-isopropylidene-α-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 100-51-6 benzyl alcohol 
• 337903-23-8 3,5-O-[2-((S)-oxiranyl)benzylidene]-1,2-O-isopropylidene-α-D-xylofuranose 

Relevant academic research and scientific papers

Facile separation of chiral 1,3-dihydrobenzo[c]furan derivatives using a D-xylose moiety as a protecting group

1,2-O-Isopropylidene-α-D-xylofuranose has been used to protect one aldehyde group of o-phthalaldehyde. This chiral protecting group acts as a resolving agent and this leads to separable diastereoisomers when a new stereogenic centre is created by the conversion of the second aldehyde group to a benzyloxyhydroxyethyl chain. These separated diastereoisomers were cyclised to 1,3-dihydrobenzo[c]furans with retention of chiral integrity at the C3 site thus allowing further elaboration to enantiomerically pure nucleoside analogues.