337923-05-4Relevant academic research and scientific papers
ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: Potential application for the treatment of amyotrophic lateral sclerosis
Chen, Tian,Benmohamed, Radhia,Kim, Jinho,Smith, Karen,Amante, Daniel,Morimoto, Richard I.,Kirsch, Donald R.,Ferrante, Robert J.,Silverman, Richard B.
experimental part, p. 515 - 527 (2012/03/26)
Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease currently without a cure. The arylsulfanyl pyrazolone (ASP) scaffold was one of the active scaffolds identified in a cell-based high throughput screening assay targeting mutant Cu/
TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
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Page/Page column 112, (2010/07/10)
The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
