337981-30-3Relevant academic research and scientific papers
Synthesis of a benzotriazole phosphoramidite for attachment of oligonucleotides to metal surfaces
Brown, Rachel,Smith, W. Ewen,Graham, Duncan
, p. 2197 - 2200 (2001)
A method for the addition of a benzotriazole moiety to the 5′-terminus of an oligonucleotide via phosphoramidite chemistry has been developed. Use of a monomethoxytrityl protecting group on the benzotriazole allowed fast on column detritylation purification by reverse-phase HPLC. Surface enhanced Raman scattering (SERS) of the modified oligonucleotides was obtained from silver colloid.
