3380-62-9

Basic information

• Product Name: N,N-dimethyl-4-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)aniline
• Synonyms: benzenamine, N,N-dimethyl-4-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-; N,N-Dimethyl-4-(2,3,4,9-tetrahydro-1H-.beta.-carbolin-1-yl)aniline; N,N-Dimethyl-4-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)aniline; N,N-Dimethyl-N-(4-(2,3,4,9-tetrahydro-1H-.beta.-carbolin-1-yl)phenyl)amine
• CAS NO: 3380-62-9
• Molecular Formula: C₁₉H₂₁N₃
• Molecular Weight: 291.3901
• Mol File: 3380-62-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 495.7°C at 760 mmHg
• Flash Point: 253.6°C
• Density: 1.18g/cm³
• Vapor Pressure: 5.75E-10mmHg at 25°C
• Refractive Index: 1.675
• CAS DataBase Reference: N,N-dimethyl-4-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-4-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)aniline(3380-62-9)
• EPA Substance Registry System: N,N-dimethyl-4-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)aniline(3380-62-9)

Safety Data

• Hazardous Substances Data: 3380-62-9(Hazardous Substances Data)

Upstream product

• 61-54-1 tryptamine 
• 100-10-7 4-dimethylamino-benzaldehyde 

Relevant articles and documents

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Tetrahydro Beta-carboline derivative as well as preparation method and application of derivative

The invention discloses a tetrahydro Beta-carboline derivative shown in a formula I as described in the specification, which is a novel compound with histone deacetylase inhibiting activity and can beused for treating some diseases with abnormally high expression of histone deacetylase effectively. The histone deacetylase is closely related to occurrence and development of cancers. The serial compounds can inhibit proliferation of tumor cells effectively by inhibiting the activity of the histone deacetylase and inducing differentiation and apoptosis of the tumor cells, so as to achieve the purpose of treating cancers.

Water as an efficient medium for the synthesis of tetrahydro-β-carbolines via Pictet-Spengler reactions

A mild and efficient protocol for the Pictet-Spengler reaction in water using an acid catalyst has been described. The condensation of tryptophan, tryptamine, and Nb-benzyl tryptophan with different aldehydes having both electron-withdrawing and -donating substituents in the presence of a catalytic amount of TFA in water furnished tetrahydro-β-carbolines in good isolated yields. A salient feature of the water mediated Pictet-Spengler reaction was the general trend observed during the condensation of Trp-OMe and aryl/aliphatic aldehydes furnishing diastereomeric mixtures with a preference for the cis-isomer.