3380-80-1

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-chlorophenyl)-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride is used as a central nervous system stimulant and hallucinogenic drug for [application reason]. Its pharmacological effects are being studied for potential therapeutic applications in treating neurodegenerative diseases and various psychiatric disorders.
Used in Cancer Therapy:
In the field of oncology, 1-(4-chlorophenyl)-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride is used as a potential therapeutic agent for cancer treatment. 1-(4-chlorophenyl)-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride has demonstrated its ability to induce apoptosis in cancer cells, making it a promising candidate for further research and development in cancer therapy.
Used in Research and Development:
1-(4-chlorophenyl)-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride is also utilized in research and development settings to explore its full range of pharmacological activities and potential applications in medicine. Its diverse effects on the central nervous system and its potential role in treating various diseases make it an interesting compound for scientists to study and develop new therapeutic strategies.

InChI:InChI=1/C17H15ClN2.ClH/c18-12-7-5-11(6-8-12)16-17-14(9-10-19-16)13-3-1-2-4-15(13)20-17;/h1-8,16,19-20H,9-10H2;1H

Upstream product

• 61-54-1 tryptamine 
• 104-88-1 4-chlorobenzaldehyde 
• 139655-00-8 [1-(4-Chloro-phenyl)-meth-(E)-ylidene]-[2-(1H-indol-3-yl)-ethyl]-amine 
• 343-94-2 tryptamine hydochloride 

Downstream Products

• 139655-03-1 (±)-1-(4-chlorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 

Relevant academic research and scientific papers

Asymmetric Biocatalytic Synthesis of 1-Aryltetrahydro-β-carbolines Enabled by “Substrate Walking”

Stereoselective catalysts for the Pictet–Spengler reaction of tryptamines and aldehydes may allow a simple and fast approach to chiral 1-substituted tetrahydro-β-carbolines. Although biocatalysts have previously been employed for the Pictet–Spengler react

AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER

The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti-cancer agent.

METHOD OF SCREENING FOR AGENTS FOR DIFFERENTIATING STEM CELLS

The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti-cancer agent.

Synthesis of 1-aryl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles (1,2,3,4-tetrahydro-β-carbolines) under high pressures

The reactions of aromatic aldehydes with tryptamine (1) in solvents of different polarity were studied. The yields of carbolines in the chosen media decrease with an increase in the donating properties of the aryl substituent, but they markedly increase a