33806-74-5Relevant academic research and scientific papers
Hydrothermal synthesis of a paramagnetic alkali supermolecule, its effect on catalase inhibitory by spectroscopic and theoretical investigation
Razmara, Zohreh,Shahraki, Somaye,Shiri, Fereshteh
, (2020)
A sodium-based hydrogen maleate supercomplex formulated as [NaH(C4H2O4). 3H2O]n; Na complex (C4H2O4 = maleate) has been synthesized by a hydrothermal process at 120 °C for 48 h. The structure of Na complex has been investigated by elemental analysis, atomic absorption spectroscopy (AAS), Fourier-transform infrared (FT-IR) spectroscopy, thermal gravimetric analysis (TGA), differential thermal analysis (DTA), single-crystal X-ray diffraction (SC-XRD) and vibration sample magnetometer (VSM). The crystallography results revealed a triclinic structure of expected composition with space group P-1. Magnetic measurements in the applied field of ±15kOe revealed that Na complex has a paramagnetic behavior at room temperature. Furthermore, the thermal behavior of Na complex revealed a good stability for it. Catalase as an antioxidant enzyme plays a crucial role in the regulation of redox state. In this study, Na complex was used to investigate its effects on bovine liver catalase (BLC) and explore the underlying mechanism. Na complex interacts with BLC mainly via Van der Waals forces and hydrogen bonds. These interactions result in the decrease of BLC catalytic activity to 31percent. UV–Vis, synchronous and 3D fluorescence spectral results confirmed that the prepared complex induced some structural changes of BLC. Molecular docking also revealed the specific binding mode of Na complex with BLC.
