33813-05-7Relevant academic research and scientific papers
Ring-opening of isoxazolidine nucleus: Competitive formation of α,β-enones and tetrahydro-1,3-oxazines
Casuscelli, Franco,Chiacchio, Ugo,Rescifina, Antonio,Romeo, Roberto,Romeo, Giovanni,Tommasini, Silvana,Uccella, Nicola
, p. 2979 - 2990 (2007/10/02)
Treatment of isoxazolidine derivatives with methyl iodide, followed by simple heating with aqueous NaOH, gives rise to a competitive formation of α,β-enones and tetrahydro-1,3-oxazines. The ring-opening process is controlled by the stereochemistry of H5 which represents the driving factor of two competitive reaction routes.
