33821-58-8

Basic information

• Product Name: CHEMBRDG-BB 4002882
• Synonyms: CHEMBRDG-BB 4002882;6-METHYL-4-OXO-1,4-DIHYDROPYRIDINE-3-CARBOXYLIC ACID;6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid(SALTDATA: FREE);1,4-dihydro-6-Methyl-4-oxopyridine-3-carboxylic acid;4-keto-6-methyl-1H-pyridine-3-carboxylic acid;6-methyl-4-oxo-1H-pyridine-3-carboxylic acid;6-Methyl-4(1H)-pyridone-3-carboxylic acid
• CAS NO: 33821-58-8
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• Mol File: 33821-58-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 311.056 °C at 760 mmHg
• Flash Point: 141.922 °C
• Appearance: /Solid
• Density: 1.346 g/cm³
• CAS DataBase Reference: CHEMBRDG-BB 4002882(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 4002882(33821-58-8)
• EPA Substance Registry System: CHEMBRDG-BB 4002882(33821-58-8)

Safety Data

• Hazardous Substances Data: 33821-58-8(Hazardous Substances Data)

Usage

General Description

CHEMBRDG-BB 4002882 is a chemical compound with the molecular formula C23H31N3O3. It is classified as a kinase inhibitor and is used for research purposes in the development of pharmaceuticals. It is known to inhibit the activity of various protein kinases, which are enzymes involved in the regulation of cell growth, proliferation, and survival. The compound has potential applications in the treatment of cancer and other diseases related to abnormal kinase activity. Its exact mechanisms of action and specific target kinases are still being studied, and further research is needed to fully understand its therapeutic potential.

Upstream product

• 10350-10-4 ethyl 1,2-dihydro-2-oxo-4-hydroxy-6-methylpyridine-3-carboxylate 
• 33821-61-3 3-((dimethylamino)methylene)-6-methyl-2H-pyran-2,4(3H)-dione 
• 86129-63-7 ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate 
• 111974-39-1 Ethyl 4-ethoxy-6-methylpyridine-3-carboxylate 
• 111974-38-0 4-methoxy-6-methyl-nicotinic acid ethyl ester 
• 111953-15-2 Ethyl 2-chloro-4-ethoxy-6-methylpyridine-3-carboxylate 
• 111953-14-1 2-chloro-4-methoxy-6-methylnicotinic acid ethyl ester 

Downstream Products

• 88252-05-5 6-(2-Hydroxy-2-phenyl-ethyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid tert-butyl ester 
• 1569643-20-4 1-isopropyl-6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide 
• 1569643-14-6 1-ethyl-6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide 
• 1569649-47-3 6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid (5-methanesulfonyl-pyridin-2-ylmethyl)-amide 
• 1569649-42-8 6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 
• 1569649-04-2 1-(2-fluoro-ethyl)-6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide 
• 1569649-33-7 6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide 
• 244638-94-6 1,4-Dihydro-3-iodo-2-methyl-4-oxo-5-pyridinecarboxylic acid 
• 86788-98-9 5-bromo-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 
• 118366-01-1 6-methyl-4-(1H)-pyridone-3-carboxylic acid benzyl ester 
• 88252-20-4 4-Oxo-6-((E)-styryl)-1,4-dihydro-pyridine-3-carboxylic acid 
• 88252-34-0 6-[2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid tert-butyl ester 
• 88252-25-9 4-Oxo-6-[(E)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-1,4-dihydro-pyridine-3-carboxylic acid 
• 886372-05-0 methyl 4-chloro-6-methylpyridine-3-carboxylate 

Relevant articles and documents

[4-(Phenoxy)pyridin-3-yl]methylamines: A new class of selective noradrenaline reuptake inhibitors

[4-(Phenoxy)pyridine-3-yl]methylamines are disclosed as a new series of selective noradrenaline reuptake inhibitors (NRI). Structure-activity relationships established that potent NRI activity could be achieved by appropriate substitution at the 2-position of the phenoxy ring. Compound 31 demonstrated potent NRI activity combined with good selectivity over serotonin and dopamine reuptake and no significant off-target pharmacology.

An Easy and Convenient Synthesis of 6-Methyl-4(1H)-pyridone-3-carboxylic Acid

A new and easy synthesis of 6-methyl-4(1H)-pyridone-3-carboxylic acid (5), an important component of broad spectrum cephalosporins, is described.It starts from the readily available ethyl 4-hydroxy-6-methyl-2(1H)-pyridone-3-carboxylate (1), which is treated with phosphoryl chloride to give ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate (2).Selective substitution of the chlorine in 4-position with alkoxide ion leads to the 4-alkoxypyridine derivatives 3.Hydrogenolysis of 3 affords ethyl 4-alkoxy-6-methyl-pyridine-3-carboxylates 4; which are hydrolysed to 5 in one step.