33837-37-5

Upstream product

• 33837-36-4 2,6-dimethoxy-3,5-diphenyl-pyrazine 
• 33837-38-6 1-hydroxy-3,5-diphenyl-1H-pyrazin-2-one 
• 67714-55-0 3,5-dichloro-2,6-diphenylpyrazine 

Downstream Products

• 75156-78-4 1,4,7-triphenyl-4,9,11-triazatricyclo<5.3.1.0^2.6>undecane-3,5,8,10-tetraone 
• 75156-74-0 1,5,6-triphenyl-3,8-diazabicyclo<3.2.1>oct-6-ene-2,4-dione 
• 75156-77-3 (Z)-2-(3,5-Dioxo-2,6-diphenyl-2,3,4,5-tetrahydro-pyrazin-2-yl)-but-2-enedioic acid dimethyl ester 
• 75156-76-2 dimethyl 1,5-diphenyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>oct-6-ene-6,7-dicarboxylate 
• 75156-79-5 diethyl 2,4-dioxo-1,5-diphenyl-3,8-diazabicyclo<3.2.1>octane exo-6,endo-7-dicarboxylate 
• 75156-79-5 diethyl 2,4-dioxo-1,5-diphenyl-3,8-diazabicyclo<3.2.1>octane endo-6,endo-7-dicarboxylate 
• 75156-75-1 1,5,6,7-tetraphenyl-3,8-diazabicyclo<3.2.1>oct-6-ene-2,4-dione 

Relevant academic research and scientific papers

Studies on pyrazines. Part 34. Synthetic approach, stability and tautomerism of 2,6-dihydroxypyrazines

Demethylation of 2,6-dimethoxy-3,5-diphenylpyrazine with iodotrimethylsilane gives the corresponding 2,6-dihydroxy- and 2-hydroxy-6-methoxy-pyrazines, whilst the 3-methyl-5-phenyl analogue affords only monohydroxy compounds. In contrast, 2,6-dimethoxy-3,5-dimethylpyrazine decomposes completely under the demethylation conditions. Hydrolysis of 2,6-diacetoxypyrazines succeeds only in the formation of 2,6-dihydroxy-3,5-diphenylpyrazine. The stability of 2,6-dihydroxypyrazines is discussed on the basis of observations made in the synthetic approach. In addition, it has been established, on the basis of UV spectral analysis, that the 2-hydroxy-6-methoxypyrazines obtained in our work exist predominantly in the hydroxypyrazine form rather than as 1,2-dihydropyrazin-2-ones.