33837-93-3Relevant academic research and scientific papers
A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A
Xu, Jingjing,Wang, Kai,Wu, Jinlong
, p. 13747 - 13749 (2018)
Psammaplysene A, an inhibitor of FOXO1a-mediated nuclear export, has been synthesized by a concise and improved route from tyrosine-derived acid and amine fragments which were easily constructed using commercially available p-hydroxybenzaldehyde and tyramine as starting material, respectively. The strategy provides an efficient access of psammaplysene analogues that can be explored for potential pharmaceutical or biological activities.
Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides
Roiser, Lukas,Waser, Mario
supporting information, p. 2338 - 2341 (2017/05/12)
The use of Cinchona alkaloid-based chiral ammonium ylides allows for the first highly enantioselective and broadly applicable spirocyclopropanation reactions of para-quinone methides. This strategy provides a straightforward protocol toward the chiral spiro[2.5]octa-4,7-dien-6-one skeleton, which is a frequently found structural motif in important biologically active molecules.
Synthesis of spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers via 1,6-conjugate addition induced dearomatization of para-quinone methides
Gai, Kuo,Fang, Xinxin,Li, Xuanyi,Xu, Jinyi,Wu, Xiaoming,Lin, Aijun,Yao, Hequan
supporting information, p. 15831 - 15834 (2015/11/10)
An efficient one-pot approach for the synthesis of spiro[2.5]octa-4,7-dien-6-ones by employing para-quinone methides has been developed. The reaction proceeded smoothly in high yields under mild conditions without the use of metals. Moreover, all products obtained herein contained two or three consecutive quaternary centers.
A domino process for benzyne preparation: Dual activation of o-(trimethylsilyl)phenols by nonafluorobutanesulfonyl fluoride
Ikawa, Takashi,Nishiyama, Tsuyoshi,Nosaki, Toshifumi,Takagi, Akira,Akai, Shuji
supporting information; experimental part, p. 1730 - 1733 (2011/06/16)
Benzynes were generated from o-(trimethylsilyl)phenols using nonafluorobutanesulfonyl fluoride (NfF) by a domino process, i.e., the nonaflation of the phenolic hydroxyl group of o-(trimethylsilyl)phenols by NfF followed by the attack of the produced fluoride ion on the trimethylsilyl group. The generated benzyne immediately underwent various reactions to give polysubstituted benzenes.
