338386-49-5

Upstream product

• 752206-21-6 4-(tert-butyl-dimethyl-silanyloxy)-2-formyl-2-(3-oxo-butyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 752206-19-2 2-(4-bromo-3-methyl-but-3-enyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 752206-15-8 3-(tert-butyl-dimethyl-silanyloxy)-7-methyl-1-aza-spiro[4.4]non-6-ene-1-carboxylic acid tert-butyl ester 
• 752206-18-1 4-(tert-butyl-dimethyl-silanyloxy)-2-(3-oxo-butyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 752206-23-8 3-methanesulfonyloxy-8-oxo-1-aza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester 
• 752206-16-9 (3R,5R)-3-Methanesulfonyloxy-8-oxo-1-aza-spiro[4.5]dec-6-ene-1-carboxylic acid tert-butyl ester 
• 752206-24-9 3-azido-8-oxo-1-aza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester 
• 479064-46-5 C₁₃H₂₀N₂O₃ 
• 752206-14-7 (5S)-dispiro{4-methyl-1,4-diazabicyclo[3.2.1]octan-3-one-7,1'-cyclohexan-4',2-1,3-dioxolane} 
• 479064-42-1 (3S)-dispiro[3-azido-1-(tert-butoxycarbonyl)pyrrolidine-5,1'-cyclohexane-4',2''-1,3-dioxolane] 
• 479064-44-3 (3S)-dispiro[3-azido-1-(ethoxycarbonylmethyl)pyrrolidine-5,1'-cyclohexane-4',2''-1,3-dioxolane] 
• 479064-45-4 (3S)-dispiro[3-amino-1-(ethoxycarbonylmethyl)pyrrolidine-5,1'-cyclohexane-4',2''-1,3-dioxolane] 
• 114676-91-4 1-tert-butyl 2-methyl (2S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidine-1,2-dicarboxylate 
• 134441-71-7 (2S,4R)-1-boc-4-tert-butyldimethylsilylpyrrolidine-2-carbaldehyde 

Downstream Products

• 244239-39-2 (1'S,2'Z,5'S)-4'-methyl-2'-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methylene]-spiro[cyclohexane-1,7'-[1,4]diazabicyclo[3.2.1]octan]-4-one 

Relevant academic research and scientific papers

An enantioselective formal total synthesis of (-)-TAN1251A

An enantioselective total synthesis of the muscarinic inhibitor (-)-TAN1251A has been achieved. An alkylidene 1,5-CH insertion reaction was used as a key step to produce a [5,5]-spirocyclic intermediate, which was transformed into the [6,5]-spirocyclic co

N-methoxy-N-acylnitrenium ions: application to the formal synthesis of (-)-TAN1251A.

[structure: see text]. A formal synthesis of the muscarinic M(1) receptor antagonist (-)-TAN1251A (7) from L-tyrosine is described. Central to this venture has been the construction of the 1-azaspiro[4.5]decane skeleton present in the natural product by a