3384-61-0 Usage
Molecular structure
A complex molecular structure with a purine derivative, an amino group, a sulfanyl group, a nitro group, a methyl group, a hydroxymethyl group, and multiple hydroxyl groups.
Purine derivative
The compound contains a purine derivative, which is a heterocyclic aromatic organic compound. Purine derivatives are found in nucleic acids (DNA and RNA) and are essential for life processes.
Amino group attachment
The purine ring has an amino group attached to it, which is a basic functional group with a nitrogen atom and a hydrogen atom. Amino groups can form hydrogen bonds and coordinate with metal ions, which can be important for biological interactions.
Sulfanyl group
A sulfanyl group (-S) is attached to the purin-9-yl, which can potentially form disulfide bonds and interact with other biomolecules or contribute to the compound's stability in biological environments.
Methyl group
A 3-methyl group is present on the imidazole ring, which can influence the steric properties and electronic effects of the compound. Methyl groups are lipophilic and can affect the compound's solubility and membrane permeability.
Hydroxymethyl group
The compound has a hydroxymethyl group (-CH2OH) on the oxolane ring, which can participate in hydrogen bonding and form hydrophobic interactions. This group can also be involved in metabolic reactions and contribute to the compound's biological activity.
Multiple hydroxyl groups
The compound contains multiple hydroxyl (-OH) groups, which can form hydrogen bonds and participate in various chemical reactions. Hydroxyl groups can also influence the compound's solubility and stability in aqueous environments.
Pharmaceutical or biological applications
Due to its intricate structure and the presence of functional groups that can interact with biological targets, this chemical may have potential pharmaceutical or biological applications. Further research and analysis are needed to fully understand its properties and potential uses.
Check Digit Verification of cas no
The CAS Registry Mumber 3384-61-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,8 and 4 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3384-61:
(6*3)+(5*3)+(4*8)+(3*4)+(2*6)+(1*1)=90
90 % 10 = 0
So 3384-61-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H16N8O6S/c1-20-3-17-10(22(26)27)13(20)29-11-6-9(18-14(15)19-11)21(4-16-6)12-8(25)7(24)5(2-23)28-12/h3-5,7-8,12,23-25H,2H2,1H3,(H2,15,18,19)/t5-,7-,8-,12-/m0/s1
3384-61-0Relevant academic research and scientific papers
Nucleosides of Azathioprine and Thiamiprine as Antiarthritics
Krenitsky, Thomas A.,Hall, Willard W.,Selph, Jeffrey L.,Truax, James F.,Vinegar, Ralph
, p. 1471 - 1475 (2007/10/02)
Azathioprine -1H-purine> is a widely used immunosuppressive and antiarthritic drug.For the sake of comparison, the riboside, the 2'-deoxyriboside, and the arabinoside of azathioprine and its 2-amino congener, thiamiprine, were prepared by an enzymatic method.In vitro, the cytotoxicities of these aglycones and their nucleosides were similar (ED 50 = 0.8-2 μM), except for the arabinoside, which were nontoxic (ED 50 > 100 μM).In vivo, their activities were compared in the rat adjuvant arthritis model.The ribosides and 2'-deoxyribosides were less potent than their corresponding aglycons.The safety indexes of these nucleosides were comparable to those of the corresponding aglycons except for the 2'-deoxyriboside of azathioprine, which had an appreciable lower safety index than did azathioprine.Both arabinosides were inactive and nontoxic.All of the aglycons tested (6-mercaptopurine, azathioprine, 6-thioguanine, and thiamiprine) were of similar potency.However, azathioprine had a more favorable therapeutic index than did 6-mercaptopurine.Similarly, thiamiprine was safer than was 6-thiaguanine.In this model, the S-(1-methyl-4-nitro-1H-imidazol-5-yl) moiety impared greater safety to these thiopurines by decreasing toxicity but not affecting potency.
