33841-54-2

Basic information

• Product Name: 5-[2-(Cbz-aMino)ethyl]-1H-tetrazole
• Synonyms: 5-[2-(Cbz-aMino)ethyl]-1H-tetrazole
• CAS NO: 33841-54-2
• Molecular Formula: C₁₁H₁₃N₅O₂
• Molecular Weight: 247.25322
• Mol File: 33841-54-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.327±0.06 g/cm3(Predicted)
• PKA: 4.87±0.10(Predicted)
• CAS DataBase Reference: 5-[2-(Cbz-aMino)ethyl]-1H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[2-(Cbz-aMino)ethyl]-1H-tetrazole(33841-54-2)
• EPA Substance Registry System: 5-[2-(Cbz-aMino)ethyl]-1H-tetrazole(33841-54-2)

Safety Data

• Hazardous Substances Data: 33841-54-2(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 18877-96-8 3-<<(benzyloxy)carbonyl>amino>propionitrile 

Downstream Products

• 31602-64-9 2-(1H-tetrazol-5-yl)ethan-1-amine 

Relevant articles and documents

DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES

Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

New substrates and inhibitors of γ-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: Design, synthesis, and biological activity

A series of potential substrates of γ-aminobutyric acid aminotransferase (GABA-AT) with lipophilic bioisosteres of the carboxylic acid group (2-7) were synthesized and tested. Most of the synthesized compounds showed substrate activities with GABA-AT; 1H-tetrazole-5-propanamine (6) was the best of those tested. The potential time-dependent inhibitor of GABA-AT, 1H-tetrazole-5-(α-vinyl-propanamine) (8), was designed based on the structures of 6 and the antiepilepsy drug vigabatrin (4-aminohex-5-enoic acid, 1). The synthesized compound 8 showed time-dependent inhibition of GABA-AT, but its potency is lower than that of vigabatrin. Methylation of the tetrazole group in 8 resulted in loss of time-dependent activity, suggesting that the tetrazole ring, the carboxylate bioisostere, exists in its deprotonated form in the enzyme active site.