3386-00-3

Basic information

• Product Name: 17-hydroxypregn-5-ene-3,20-dione cyclic bis(ethylene acetal)
• Synonyms: 17-hydroxypregn-5-ene-3,20-dione cyclic bis(ethylene acetal);17-Hydroxypregn-5-ene-3,20-dione bis(ethylene acetal);17a-Hydroxypregn-5-ene-3,20-dione-3,20-bis(ethyleneketal);Einecs 222-203-5;17α-Hydroxypregn-5-ene-3,20-dione-3,20-bis(ethyleneketal)
• CAS NO: 3386-00-3
• Molecular Formula: C₂₅H₃₈O₅
• Molecular Weight: 418.57
• EINECS: 222-203-5
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 3386-00-3.mol

Chemical Properties

• Melting Point: 209.5-212 °C
• Boiling Point: 535.3 °C at 760 mmHg
• Flash Point: 277.6 °C
• Appearance: /
• Density: 1.21 g/cm³
• Vapor Pressure: 1.08E-13mmHg at 25°C
• Refractive Index: 1.574
• PKA: 15.05±0.60(Predicted)
• CAS DataBase Reference: 17-hydroxypregn-5-ene-3,20-dione cyclic bis(ethylene acetal)(CAS DataBase Reference)
• NIST Chemistry Reference: 17-hydroxypregn-5-ene-3,20-dione cyclic bis(ethylene acetal)(3386-00-3)
• EPA Substance Registry System: 17-hydroxypregn-5-ene-3,20-dione cyclic bis(ethylene acetal)(3386-00-3)

Safety Data

• Hazardous Substances Data: 3386-00-3(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

An intermediate for the synthesis of labelled progestogens

InChI:InChI=1/C25H38O5/c1-21-10-11-24(29-14-15-30-24)16-17(21)4-5-18-19(21)6-8-22(2)20(18)7-9-25(22,26)23(3)27-12-13-28-23/h4,18-20,26H,5-16H2,1-3H3/t18-,19+,20+,21+,22+,25-/m1/s1

Upstream product

• 60-29-7 diethyl ether 
• 19291-50-0 3,3;20,20-bis-ethanediyldioxy-16α-,17-epoxy-pregn-5-ene 
• 39932-37-1 16-dehydro-pregnenolone acetate ethylene ketal 
• 497212-74-5 20,20-ethanediyldioxy-pregna-4,16-dien-3-one 
• 39932-36-0 20,20-ethanediyldioxy-pregna-5,16-dien-3β-ol 
• 68-96-2 17-hydroxyprogesterone 
• 107-21-1 ethylene glycol 
• 23925-78-2 20,20-ethanediyldioxy-16α,17-epoxy-pregn-4-en-3-one 
• 979-02-2 16-dehydropregnenolone acetate 

Downstream Products

• 3496-78-4 3,3;20,20-bis-ethanediyldioxy-5,6α-epoxy-5α-pregnan-17-ol 
• 117898-52-9 3,3;20,20-bis-ethanediyldioxy-5,6β-epoxy-5β-pregnan-17-ol 
• 71-58-9 Medroxyprogesterone acetate 
• 520-85-4 Medroxyprogesterone 
• 52358-60-8 6α-methyl-17-propionyloxy-pregn-4-ene-3,20-dione 
• 986-96-9 3,17-diacetoxy-6-methyl-pregna-3,5-dien-20-one 
• 3496-78-4 C₂₅H₃₈O₆ 

Relevant articles and documents

Preparation method of palace progesterone

The invention relates to the technical field of preparation of pharmaceutical active pharmaceutical chemicals, in particular to a preparation method of palace progesterone. To the preparation method, 17 α - hydroxyl progesterone is used as a substrate, and nucleophilic addition reaction is carried out in sequence. An epoxidation reaction, an open-loop addition reaction, an elimination reaction, an esterification reaction and a hydrolysis reaction are adopted to obtain the toecliptin progesterone, and a precious metal catalyst and a carcinogenic solvent are not used in the preparation process simultaneously. ≥ 91%.

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