33867-36-6

Usage

Uses

Used in Pharmaceutical Industry:
5-Oxaspiro[2.4]heptan-6-one is used as a key building block for the synthesis of various pharmaceuticals due to its unique spiro ring structure, which allows for the creation of a wide range of biologically active compounds.
Used in Flavor and Fragrance Industry:
5-Oxaspiro[2.4]heptan-6-one is used as a flavoring agent in the food industry, enhancing the taste profiles of various products. Its unique chemical properties contribute to the development of distinct flavor profiles.
Used in Perfume Production:
In the fragrance industry, 5-Oxaspiro[2.4]heptan-6-one is utilized as a fragrance ingredient, adding depth and complexity to perfume compositions. Its versatility in chemical interactions allows for the creation of a broad spectrum of scents.

Upstream product

• 7440-66-6 zinc 
• 157-46-0 2-Oxa-spiro<3,2>hexan 
• 201230-82-2 carbon monoxide 

Downstream Products

• 142148-13-8 1-hydroxymethylcyclopropylacetic acid methyl ester 

Relevant academic research and scientific papers

Efficient Synthesis of γ-Lactones by Cobalt-Catalyzed Carbonylative Ring Expansion of Oxetanes under Syngas Atmosphere

A practical route from oxetane or thietane to γ-(thio)butyrolactone via solvated-proton-assisted cobalt-catalyzed carbonylative ring expansion under syngas atmosphere has been established. A wide variety of γ-(thio)butyrolactones can be afforded in good to excellent yields. The versatility of this method has been well demonstrated in the synthesis of intermediates towards the natural product Arctigenin as well as the pharmaceuticals Baclofen and Montelukast. The observed promoting effect of glycol ether solvent has been rationally interpreted.

Synthesis method of butyrolactone compound

The invention relates to a synthesis method of a butyrolactone compound. The synthesis method comprises the following step: in the presence of a solvent and a cobalt catalyst, converting an oxetane compound shown as general formula I into a butyrolactone compound shown as general formula II through carbonyl insertion ring expansion reaction in an atmosphere of CO and H2. Compared with an existingmethod for synthesizing butyrolactone through oxetane carbonylation ring expansion reaction in a carbon monoxide atmosphere, the synthesis method of a butyrolactone compound provided by the inventionhas the advantages of excellent catalytic activity, excellent chemical selection, wide substrate applicability, mild reaction conditions and the like; compared with other methods for synthesizing butyrolactone compounds, the method provided by the invention has the advantages of wide substrate range, high atom economy, no need of noble metal catalysis and the like, therefore the method has a wideapplication prospect.

NOVEL HIV REVERSE TRANSCRIPTASE INHIBITORS

The invention is related to compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, ester, and/ or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Process and intermediate products for the production of 5-oxaspiro [2.4]heptan-6-one

5-Oxaspiro[2.4]heptan-6-one: STR1 is obtained from [3-(hydroxymethyl)oxetan-3-yl]acetonitrile by reaction with hydrogen bromide and then cyclizing the intermediate product 4,4-bis(bromomethyl)dihydro-2-furanone with zinc. 5-Oxaspiro[2.4]heptan-6-one is an intermediate product for the production of leukotriene antagonists.