3387-86-8 Usage
Uses
Used in Pharmaceutical Industry:
Tyrosine, 3-aminois used as a precursor for the production of neurotransmitters such as dopamine, epinephrine, and norepinephrine, which are vital for cognitive function, mood regulation, and stress response. It is also used in the synthesis of thyroid hormones, which regulate metabolism and energy production.
Used in Cosmetic Industry:
Tyrosine, 3-aminois used as a precursor for the pigment melanin, which gives color to the hair, skin, and eyes. It is incorporated into cosmetic products to enhance skin pigmentation and provide a natural tan.
Used in Nutritional Supplements:
Tyrosine, 3-aminois used as a dietary supplement to support cognitive function, mood, and stress response. It is particularly beneficial for individuals under high-stress conditions, such as athletes and military personnel, to improve mental performance and resilience.
Used in Research and Development:
Tyrosine, 3-aminois used in scientific research to study the role of neurotransmitters and hormones in various physiological processes and to develop new therapeutic agents for the treatment of neurological and psychiatric disorders.
It is important to use tyrosine supplements with caution and under the guidance of a healthcare professional, as excessive levels can have negative effects on the body.
Check Digit Verification of cas no
The CAS Registry Mumber 3387-86-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,8 and 7 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3387-86:
(6*3)+(5*3)+(4*8)+(3*7)+(2*8)+(1*6)=108
108 % 10 = 8
So 3387-86-8 is a valid CAS Registry Number.
3387-86-8Relevant academic research and scientific papers
Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus
Wakamatsu, Kazumasa,Tabuchi, Keisuke,Ojika, Makoto,Zucca, Fabio A.,Zecca, Luigi,Ito, Shosuke
, p. 768 - 776 (2015/11/11)
In order to elucidate the chemical structure of black to brown pigments, neuromelanins (NMs), in the substantia nigra (SN) and the locus coeruleus (LC) in the central nervous system of humans and other mammalian species during aging, chemical degradative methods are powerful tools. HPLC analysis after hydroiodic acid hydrolysis detected aminohydroxyphenylethylamines, aminohydroxyphenylacetic acids, and aminohydroxyethylbenzenes, which confirmed that SN-NM and LC-NM contain melanin derived not only from dopamine and norepinephrine (NE) but also from several other catecholic metabolites, such as 3,4-dihydroxyphenylalanine, 3,4-dihydroxyphenylacetic acid, 3,4-dihydroxymandelic acid, 3,4-dihydroxyphenylethanol, and 3,4-dihydroxyphenylethylene glycol, in addition to the corresponding Cys-derivatives in varying degrees. However, hydroiodic acid hydrolysis showed that LC-NM produced the same degradation products as were detected in SN-NM. Thus, we needed to develop a new chemical detection method to validate the existence of NE in LC-NM. In the present study, we report that HCl hydrolysis of LC-NM in the presence of thioglycolic acid yields new products arising from substitution of the hydroxyl group by thioglycolic acid at the benzyl position of NE and cysteinyl-NE. This is the first chemical evidence showing that NE and cysteinyl-NE are incorporated into LC-NM.
