338733-24-7

Upstream product

• 338733-23-6 3-(4-chloro-benzyl)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid ethyl ester 
• 617714-57-5 3-(4-Chloro-benzylidene)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester 
• 185099-67-6 Boc-tropinone 
• 5632-84-8 nortropinone 
• 532-24-1 tropinone 
• 750634-13-0 3-(4-chloro-benzyl)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester 

Downstream Products

• 617714-61-1 {2-[3-(4-chloro-benzyl)-8-aza-bicyclo[3.2.1]oct-8-yl]-1-methyl-2-oxo-ethyl}-carbamic acid tert-butyl ester 
• 617714-62-2 {(1R,2S)-1-[3-(4-Chloro-benzyl)-8-aza-bicyclo[3.2.1]octane-8-carbonyl]-2-hydroxy-propyl}-carbamic acid tert-butyl ester 
• 338733-04-3 2-[3-(4-chloro-benzyl)-8-aza-bicyclo[3.2.1]oct-8-ylmethyl]-1H-benzimidazole 
• 338733-13-4 4-{3-[3-(4-chloro-benzyl)-8-aza-bicyclo[3.2.1]oct-8-yl]-propyl}-phenol 
• 617714-64-4 {(1S,2S)-1-[3-(4-Chloro-benzyl)-8-aza-bicyclo[3.2.1]oct-8-ylmethyl]-2-hydroxy-propyl}-carbamic acid tert-butyl ester 
• 617714-63-3 {2-[3-(4-chloro-benzyl)-8-aza-bicyclo[3.2.1]oct-8-yl]-1-methyl-ethyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Bridged bicyclic amine derivatives useful as CCR-3 receptor antagonists

Compounds having the formula (I), Ar—(F)(E)-(CR3R4)—(CHR5)m-(T)-(Q)-Ar1, are useful as CCR-3 receptor antagonists, wherein T is a bridged heterocyclyl group having one N atom and a bridge of one to two bridgehead carbon atoms; Ar and Ar1 are aryl or heteroaryl; F is alkylene, alkenylene, or a bond; E is —C(═O)N(R10)—, —SO2N(R10)—, —N(R11)C(═O)N(R10O)—, —N(R11)SO2N(R10)—, —N(R11)C(═S)N(R10)—, —N(R11)C(═O)—, —N(R11)SO2—, —N(R12)C(═O)CH(R13)—, or CH(R13)C(═O)N(R12)—; Q is —C(═O)— or C1-2alkylene; and R3, R4, R5, R9, R10, R11, R12, and R13 are defined as set forth in the specification.

Design and synthesis of novel CCR3 antagonists

As part of our investigation into the development of potent CCR3 antagonists, a series of piperidine analogues was designed and prepared. Exploration of the piperidine core examined both the basicity and the location of a nitrogen, as well as conformational variants. The bicyclo-piperidine 24c was found to be the most potent inhibitor of CCR3 with an IC50 of 0.0082 μM in the binding assay and 0.0024 μM in the chemotaxis assay.

8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists

Novel 3-substituted 8-aza-bicyclo[3.2.1]octanes (commonly known as “tropanes”) substituted in the 8-position are effective as NMDA NR2B antagonists useful for relieving pain.