338749-99-8Relevant academic research and scientific papers
A Unified Approach to Couple Aromatic Heteronucleophiles to Azines and Pharmaceuticals
Anderson, Ryan G.,Jett, Brianna M.,McNally, Andrew
supporting information, p. 12514 - 12518 (2018/09/10)
Coupling aromatic heteronucleophiles to arenes is a common way to assemble drug-like molecules. Many methods operate via nucleophiles intercepting organometallic intermediates, via Pd-, Cu-, and Ni-catalysis, that facilitate carbon-heteroatom bond formation and a variety of protocols. We present an alternative, unified strategy where phosphonium salts can replicate the behavior of organometallic intermediates. Under a narrow set of reaction conditions, a variety of aromatic heteronucleophile classes can be coupled to pyridines and diazines that are often problematic in metal-catalyzed couplings, such as where (pseudo)halide precursors are unavailable in complex structures with multiple polar functional groups.
Microwave-Assisted Metal- and Ligand-Free O-Arylation of Quinolones Using Diaryliodonium Salts: An Easy and Rapid Synthesis of Aryloxyquinolines
Mehra, Manish Kumar,Tantak, Mukund P.,Kumar, Indresh,Kumar, Dalip
supporting information, p. 604 - 610 (2016/03/12)
A microwave-assisted metal- and ligand-free direct O-arylation of quinolones has been achieved by employing easily accessible diaryliodonium salts in the presence of a base to afford various aryloxyquinolines in good yields. The operationally simple and r
