33875-34-2Relevant academic research and scientific papers
The synthesis and stereospecific solid-state photodecarbonylation of hexasubstituted meso- and d,l-ketones
Shiraki, Saori,Natarajan, Arunkumar,Garcia-Garibay, Miguel A.
experimental part, p. 1480 - 1487 (2012/06/01)
Tertiary carbanions were trapped with half an equivalent of diphosgene to give meso- and d,l-hexasubstituted ketones in moderate yields and modest diastereoselectivities. The ketones were also synthesized by a step-wise synthesis in which the carbonyl group was first installed as an acid before activation and the second nucleophilic attack. This second method gave lower yields but similar diastereoselectivites. Steric limits of both methods were also determined. The photolysis of the resulting crystalline ketones gave a mixture of products in solution, but took place chemoselectively and diastereospecifically in the solid-state. The Royal Society of Chemistry and Owner Societies.
SINTESIS ASIMETRICA DE α-FENILAMINOACIDOS
Cativiela, Carlos,Villegas, Maria D. Diaz de,Galvez, Jose A.,Lapena, Yolanda
, p. 432 - 437 (2007/10/02)
A new synthetic strategy to obtain α-phenylamino acids in enantiomerically pure form is described.The new route is based on the highly diastereoselective alkylation of (1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-phenylcyanoacetate and subsequent Curtiu
Racemic and Optically Active Hydantoins from Disubstituted Cyanoacetic Acids
Knabe, Joachim,Wunn, Wolfgang
, p. 538 - 543 (2007/10/02)
Starting from the chiral disubstituted cyanoacetic acids 1 the racemates and some enantiomers of the 5,5-disubstituted hydantoins 6 and of the 3-methylhydantoins 7 are synthesized via the isocyanates 3.Their absolute configurations are determined.
