33875-63-7

Upstream product

• 6575-13-9 2,6-dimethylbenzonitrile 
• 576-22-7 2-Bromo-m-xylene 

Downstream Products

• 126694-42-6 8-Cyan-N-(p-tolylsulfonyl)-1-thia-10-aza<2.2>metacyclophan 
• 131298-27-6 8-Cyan-17,17,18,18-tetradehydro-1,10-bis(p-tolylsulfonyl)-1,10-diaza<2>(1,3)benzeno<2>(1,2)benzeno<2>(1,2)benzenophan 
• 126694-53-9 8-Cyan-N-(p-tolylsulfonyl)-1-thia-10-aza<2.2>metacyclophan-1,1-dioxid 

Relevant academic research and scientific papers

Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere via N-H imines as an intramolecular directing group

Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere was developed starting from carbonitriles and Grignard reagents via N-H imine intermediates. The present process is characterized by the following two-step sequence in a one-pot manner: (1) addition of Grignard reagents to carbonitriles to form N-H imines and (2) benzylic C-H oxygenation (C=O bond formation) triggered by 1,5-hydrogen atom transfer with transient iminyl copper species.