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Relevant academic research and scientific papers

Efficient green procedure for the synthesis of coumarin derivatives by a one-pot, three-component reaction under solvent-free conditions

A simple, efficient, and general method has been developed for the synthesis of coumarin derivatives through a one-pot reaction of aromatic aldehydes, 2,2-dimethyl-1,3-dioxane-4,6-dione and 5,5-dimethyl-1,3- cyclohexanedione, in the presence of TEBA under solvent-free conditions using grinding methods. The mild reaction conditions, simple protocol, high yields, and cleaner reaction make this protocol practical and economically attractive. Copyright Taylor & Francis Group, LLC.

A convenient synthesis of 4-aryl-7,7-dimethyl-5-oxo- 3,4,5,6,7,8-hexahydrcoumarin under microvave irradiation without catalyst

A series of hexahydrocoumarins 4 were synthesized by the reaction of aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexandione and meldiums acid under microwave irradiation without catalyst. The structure of 4a was determined by x-ray analysis.

Enantioselective synthesis of fused dihydropyranones via squaramide-catalyzed Michael addition/lactonization cascade reaction

A highly enantioselective (49–99% ee) Michael addition/lactonization cascade process has been developed to construct 3,4-dihydropyran-2-one in the presence of a bifunctional squaramide. Various α,β-unsaturated N-acyl heterocycles were well tolerated and afforded 3,4-dihydropyran-2-ones in moderate to excellent isolated yields (50–99%). Both cyclic and acyclic β-diketones functioned as appropriate donors. The resulting 3,4-dihydropyran-2-ones could be readily converted into oxadecalinones.

Synthesis of dihydropyranones and dihydropyrano[2,3-d][1,3]dioxine-diones by cyclization reaction of Meldrum's acid with arylaldehydes and 1,3-dicarbonyls under thermal and ultrasound irradiation

The present paper deals with the synthesis of novel dihydropyranone and dihydropyrano[2,3-d][1,3]dioxinedione derivatives via one-pot three-component reaction between Meldrum's acid, arylaldehydes, and various 1,3-dicarbonyls in the presence of KOH as a base in H2O:EtOH under thermal and ultrasound irradiation. It was observed that ultrasound-Assisted method gave 80-94% yields in 30-45 min as against 120-280 min required to get 60-82% yields by thermal method. Formula parented.

A highly efficient CuI nanoparticles-catalyzed synthesis of tetrahydrochromenediones and dihydropyrano[c]chromenediones under grinding

A concise and CuI nanoparticle-catalyzed synthesis of tetrahydrochromenediones and dihydropyrano[c]chromenediones under solvent-free grinding conditions via the three-component condensation reaction of Meldrum's acid, an aromatic aldehyde, and an active m

Three-component processes for the synthesis of 4-aryl-7,7-dimethyl- 5-oxo-3,4,5,6,7,8-hexahydrocoumarin in aqueous media

The reaction of an aromatic aldehyde, isopropylidene malonate and 5,5-dimethyl- 1,3-cyclohexanedione in water in the presence of triethylbenzylammonium chloride (TEBA) as catalyst affords a one-pot synthesis of 4-aryl-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin.