33889-68-8 Usage
Uses
Fangchinoline is an isolate from Stephania Tetrandra that shows anti-cancer activity. It inhibits breast adenocarcinoma proliferation through apoptosis induction. In addition, it has been shown to inhibit HIV-Type 1 replication.
Description
Thalictrum rugosum Ait also contains this alkaloid which is dextrorotatory with
[o:lbo + 128° (MeOH). The ultraviolet spectrum of this base consists of a single
absorption maximum at 283 flI/J..
References
Mitscher et al., Chem. Commun., 589 (1971)
Check Digit Verification of cas no
The CAS Registry Mumber 33889-68-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,8,8 and 9 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 33889-68:
(7*3)+(6*3)+(5*8)+(4*8)+(3*9)+(2*6)+(1*8)=158
158 % 10 = 8
So 33889-68-8 is a valid CAS Registry Number.
InChI:InChI=1/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3
33889-68-8Relevant articles and documents
Design, synthesis and in vitro anticancer research of novel tetrandrine and fangchinoline derivatives
Gao, Xiu-zheng,Lv, Xu-tao,Zhang, Rui-rui,Luo, Yang,Wang, Mu-xuan,Chen, Jia-shu,Zhang, Yu-kai,Sun, Bin,Sun, Jin-yue,Liu, Yu-fa,Liu, Chao
, (2021/02/22)
Cancer treatment is one of the major public health issues in the world. Tetrandrine (Tet) and fangchinoline (d-Tet) are two bis-benzyl isoquinoline alkaloids extracted from Stephania tetrandra S. Moore, and their antitumor activities have been confirmed.
REGIOSELECTIVE O-DEMETHYLATION OF BISBENZYLISOQUINOLINE ALKALOIDS
Kunitomo, Jun-ichi,Oshikata, Megumi,Akasu, Michinori,Ishii, Hisashi
, p. 937 - 942 (2007/10/02)
The cleavage of methyl ethers of several bisbenzylisoquinoline alkaloids was studied and regioselective O-demethylation was observed.