338956-90-4

Upstream product

• 192573-33-4 (1S,3aR,7aR)-1-[(S)-1-(3-methyl-3-trimethylsilyloxybutyloxy)ethyl]-7a-methyloctahydro-1H-inden-4-one 
• 215929-37-6 (Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylideneethyl]diphenylphosphine oxide 
• 103909-75-7 maxacalcitol 
• 338956-87-9 (1S,3aR,4S,7aS)-4-hydroxy-1-[(S)-1-(3-methyl-3-trimethylsilyloxybutyloxy)ethyl]-7a-methyloctahydro-1H-indene 
• 221696-52-2 (1S,3aS,7aS)-7a-Methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-trimethylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(S)-1-(3-methyl-3-trimethylsilanyloxy-butoxy)-ethyl]-octahydro-indene 
• 215929-41-2 (Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylidene]ethanol 
• 216380-59-5 (Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylidene]-1-chloroethane 

Relevant academic research and scientific papers

Synthesis and evaluation of A-ring diastereomers of 1α,25-dihydroxy-22-oxavitamin D3 (OCT)

A-ring diastereomers of 1α,25-dihydroxy-22-oxavitamin D3 (OCT) (2), 3-epi-1α,25-dihydroxy-22-oxavitamin D3 (3-epiOCT) (3) and 1,3-diepi-1α,25-dihydroxy-22-oxavitamin D3 (1,3-diepiOCT) (4) were synthesized by the convergent method. In vitro binding affinity for rat vitamin D binding protein and calf-thymus vitamin D receptor, differentiation-inducing activity on HL-60 cells, and transcriptional activity of 3-epiOCT (3) and 1,3-diepiOCT (4) were evaluated in comparison with OCT (2), 1-epi-1α,25-dihydroxy-22-oxavitamin D3 (1-epiOCT) (5) and 1α,25-dihydroxyvitamin D3 (1).

VITAMIN D DERIVATIVES AND PROCESS FOR PRODUCING THE SAME

The object of the present invention is to provide a novel 22-oxavitamin D derivative having a hydroxy group at both 1α- and 3α-positions. According to the present invention, there is provided 22-oxavitamin D derivatives having the following general formul