338982-11-9

Usage

Structural Features

Heterocyclic aromatic organic compound
Contains an isoxazole ring
Includes a chlorophenyl group
Features a carboxylic acid functional group

Potential Pharmaceutical Applications

Due to its structural features, it holds promise for pharmaceutical applications.

Synthesis Potential

It can be utilized in the synthesis of other organic compounds, including pharmaceutical drugs or agrochemicals.

Research and Development Significance

Valuable compound for research and development in medicinal chemistry and chemical engineering.

Upstream product

• 206055-90-5 3-(4-chlorophenyl)-5-hydroxymethylisoxazole 
• 294624-23-0 (Z)-ethyl 4-(4-chlorophenyl)-2-hydroxy-4-oxo-2-butenoate 
• 99-91-2 para-chloroacetophenone 
• 29363-97-1 ethyl 3-(4′-chlorophenyl)isoxazole-5-carboxylate 
• 471-25-0 Propiolic acid 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 3848-36-0 4-chlorobenzaldoxime 

Relevant academic research and scientific papers

Synthesis and mechanistic studies of diketo acids and their bioisosteres as potential antibacterial agents

A series of diketo esters and their pertinent bioisosteres were designed and synthesized as potent antibacterial agents by targeting methionine amino peptidases (MetAPs). In the biochemical assay against purified MetAPs from Streptococcus pneumoniae (SpMe

Synthesis, cytotoxic activity and binding model analysis of novel isoxazole-docetaxel analogues with C3′-N modification

Structure–activity relationship (SAR) studies confirm that modifications at C-3′ position can lead to the development of highly potent novel taxoids. We designed and synthesized a series of novel isoxazole-docetaxel analogues A1–A5 by introducing isoxazol

Copper(0) Nanoparticles in Click Chemistry: Synthesis of 3,5-Disubstituted Isoxazoles

An efficient procedure for the synthesis of 3,5-disubstituted isoxazoles via [3+2] cycloaddition reaction of in situ generated nitrile oxides with acetylenes employing readily preparable copper(0) nanoparticles is described. A variety of in situ generated

Concise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins

The synthesis of a series of new 5-isoxazolpenicillins is described, which were obtained by coupling substituted isoxazoles with 6-APA. Concise large-scale synthesis of 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition using copper(I) as catalyst was also investigated. Representative compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-negative bacteria.

PHARMACEUTICALLY ACTIVE BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES

Compounds of formula (I): wherein R1, R2 and R3 are independently, hydrogen, halogen, CF3, OR6, NR7R8, NR8COR10, NR8SO2R10 or C1-6 alkyl optionally substituted by hydroxy, C1-6 alkoxy or NR7R8; R4 is NR8CONR8R9, NR8COR9, NR8SO2R9, or W-CONR8R9, where W is a bond, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene; and R5 is Formula (A) methods for their synthesis, pharmaceutical compositions comprising them and their use in medicine, in particular for the treatment of cancer.