338989-48-3Relevant academic research and scientific papers
Rapid Access to Orthogonally Functionalized Naphthalenes: Application to the Total Synthesis of the Anticancer Agent Chartarin
Unzner, Teresa A.,Grossmann, Adriana S.,Magauer, Thomas
supporting information, p. 9763 - 9767 (2016/08/10)
We report the synthesis of orthogonally functionalized naphthalenes from simple, commercially available indanones in four steps. The developed method proceeds through a two-step process that features a thermally induced fragmentation of a cyclopropane indanone with simultaneous 1,2-chloride shift. Migration of the chloride substituent occurs in a regioselective manner to preferentially afford the para-chloronaphthol substitution pattern. The obtained naphthols are versatile building blocks that can be selectively modified and used for the efficient construction of biologically active molecules. This has enabled the total synthesis of the potent anticancer natural product chartarin through a highly convergent retrosynthetic bond disconnection.
Synthesis of benzo[c]fluorenone through a one-pot cascade reaction using inden-1-one derivatives
Zheng, Shuyan,Tan, Hongsheng,Zhang, Xiaoguang,Yu, Chunhui,Shen, Zhengwu
supporting information, p. 975 - 978 (2015/02/02)
A novel one-pot thermal cycloaddition of two indenones followed by a decarbonylation and dehydrogenation cascade afforded benzo[c]fluorenones regioselectively. Various substituted indenone derivatives were converted into their corresponding benzo[c]fluorenones in good to excellent yields.
Synthesis of benzo[c]fluorenone through a one-pot cascade reaction using inden-1-one derivatives
Zheng, Shuyan,Tan, Hongsheng,Zhang, Xiaoguang,Yu, Chunhui,Shen, Zhengwu
supporting information, p. 975 - 978 (2014/02/14)
A novel one-pot thermal cycloaddition of two indenones followed by a decarbonylation and dehydrogenation cascade afforded benzo[c]fluorenones regioselectively. Various substituted indenone derivatives were converted into their corresponding benzo[c]fluorenones in good to excellent yields.
Facile synthesis of indenones from indanones: A new procedure
Hauser,Zhou,Sun
, p. 77 - 80 (2007/10/03)
A two-step procedure for the conversion of indanones to indenones is described.
