339079-81-1

Basic information

• Product Name: 1,4-Dimethoxy-3-{(2R,3R)-3-methyl-5-[(2E,4E)-6-methyl-octa-2,4-dien-(Z)-ylidene]-tetrahydro-pyran-2-yl}-5-phenyl-1H-pyridin-2-one
• CAS NO: 339079-81-1
• Molecular Weight: 449.59
• Mol File: 339079-81-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,4-Dimethoxy-3-{(2R,3R)-3-methyl-5-[(2E,4E)-6-methyl-octa-2,4-dien-(Z)-ylidene]-tetrahydro-pyran-2-yl}-5-phenyl-1H-pyridin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dimethoxy-3-{(2R,3R)-3-methyl-5-[(2E,4E)-6-methyl-octa-2,4-dien-(Z)-ylidene]-tetrahydro-pyran-2-yl}-5-phenyl-1H-pyridin-2-one(339079-81-1)
• EPA Substance Registry System: 1,4-Dimethoxy-3-{(2R,3R)-3-methyl-5-[(2E,4E)-6-methyl-octa-2,4-dien-(Z)-ylidene]-tetrahydro-pyran-2-yl}-5-phenyl-1H-pyridin-2-one(339079-81-1)

Safety Data

• Hazardous Substances Data: 339079-81-1(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 

Downstream Products

• 339079-82-2 3-((2R,3R,5S)-5-Hydroxy-3-methyl-tetrahydro-pyran-2-yl)-1,4-dimethoxy-5-phenyl-1H-pyridin-2-one 

Relevant articles and documents

Structure of TMC-69, a new antitumor antibiotic from Chrysosporium sp. TC 1068

A new antitumor antibiotic, TMC-69, possessing inhibitory activity against cdc25A phosphatase, has been isolated from the fermentation broth of a mitosporic fungus, Chrysosporium sp. TC 1068. This antibiotic was labile in solid state as well as in solution, and thus was converted to the more stable derivatives, diacetyl TMC-69 and hexahydro TMC-69, to elucidate the structure and to evaluate the biological activities. The planar structure of TMC-69 was determined, through the analysis of various NMR experiments of diacetyl TMC-69 and ESI-MS data of TMC-69, to be [5Z(E,E)]-1,4-dihydroxy-5-phenyl-3-[tetrahydro-3-methyl-5- (6-methyl-2,4-octadienylidene)-2H-pyran-2-yl]-2(1H)-pyridinone. Furthermore, the absolute configuration of tetrahydropyranyl moiety was determined by degradation studies of TMC-69, followed by the application of modified Mosher's method.