339087-07-9

Upstream product

• 339086-87-2 (S)-2-((S)-3-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-propionylamino)-3-oxo-butyric acid 2,2,2-trichloro-ethyl ester 
• 339086-88-3 2-(2-benzyloxycarbonyl-1-tert-butoxycarbonylamino-ethyl)-5-methyl-oxazole-4-carboxylic acid 2,2,2-trichloro-ethyl ester 

Downstream Products

• 339087-11-5 C₅₂H₅₃Cl₃N₆O₁₅ 
• 339086-96-3 2-((S)-1-Amino-2-benzyloxycarbonyl-ethyl)-5-methyl-oxazole-4-carboxylic acid 
• 339087-00-2 C₄₅H₄₂N₆O₁₂ 

Relevant academic research and scientific papers

Improved synthesis of functionalized molecular platforms related to marine cyclopeptides

We report an improved synthesis of new molecular platforms, functionalized for studies in molecular recognition and combinatorial chemistry. Their structures are related to naturally occurring marine cyclopeptides such as the Dolostatins and Dendroamides that feature side chain functionality positioned on the same face of a rigid platform. Incorporation of methyl substituted oxazole and thiazole rings into the platforms enhances the rigidity of structure and significantly improves the yields of the macrocyclization reaction in the synthesis.