33916-25-5Relevant academic research and scientific papers
Synthesis of the antimycobacterial naphthoquinone, 7-methyljuglone and its dimer, neodiospyrin
Van Der Kooy, Frank,Meyer, J.J. Marion
, p. 60 - 61 (2007/10/03)
We report on the laboratory-scale synthesis of the antimycobacterial naphthoquinone, 7-methyljuglone (7-methyl-5-hydroxy-1,4-naphthoquinone) in a one step Friedel-Crafts acylation reaction. This compound was used to synthesize neodiospyrin, which possesses similar bioactivity.
Synthesis of Neodiospyrin and Fixation of Aryl-Quinone Linkage in Its Structure
Kumari, L. Krishna,Babu, M. Hari,Pardhasaradhi, M.
, p. 619 - 621 (2007/10/02)
The first synthesis of neodiospyrin (I) is achieved through quinone-naphthol coupling.Sodium dithionite reduction of the dialkyl ethers of I yields hemiketals (VIa and VIb).The aryl-quinone linkage in I is shown tobe 8-3'.
