339183-18-5

Upstream product

• 339183-16-3 (R)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 161496-59-9 N-methyl-O-methyl-D-tyrosine methyl ester 
• 339183-17-4 (R)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester 

Relevant academic research and scientific papers

Synthetic studies of a didemnin B analog based on a 2,3-diamino sugar scaffolding

Reductive amination, amide formation using BOP [(1H-1,2,3-benzotriazol-1-yloxy)tris(dimethyl-amino)-phosphonium hexafluorophosphate] and esterification via DCC (dicyclohexylcarbodiimide) were the key synthetic steps to generate an advanced intermediate in the preparation of a didemnin B analog based on a sugar scaffolding (2). This analog should provide insight into the bioactive conformation of didemnin B.