339201-37-5

Basic information

• Product Name: Glycine, N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-N-[(phenylmethoxy)carbonyl] -, methyl ester
• CAS NO: 339201-37-5
• Molecular Formula: C19H16N2O6
• Molecular Weight: 368.346
• Mol File: 339201-37-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Glycine, N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-N-[(phenylmethoxy)carbonyl] -, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-N-[(phenylmethoxy)carbonyl] -, methyl ester(339201-37-5)
• EPA Substance Registry System: Glycine, N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-N-[(phenylmethoxy)carbonyl] -, methyl ester(339201-37-5)

Safety Data

• Hazardous Substances Data: 339201-37-5(Hazardous Substances Data)

Upstream product

• 287728-91-0 N-benzyloxycarbonylaminophthalimide 
• 96-32-2 bromoacetic acid methyl ester 
• 85-44-9 phthalic anhydride 
• 96-35-5 glycolic acid methyl ester 

Downstream Products

• 200813-56-5 2-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-methoxycarbonylmethylhydrazine 
• 929720-03-6 C₂₈H₃₃N₃O₈ 
• 929719-97-1 {N-benzyloxycarbonyl-N'-[2-(pyrrolidine-1-carbonyl)-benzoyl]-hydrazino}-acetic acid methyl ester 

Relevant articles and documents

Synthesis of Nα-Z, Nβ-Fmoc or Boc protected α-hydrazinoacids and study of the coupling reaction in solution of Nα-Z-α-hydrazinoesters

The preparation of chiral orthogonally protected Nα-Z, Nβ-Fmoc- or Boc-α-hydrazinoacids derivatives, directly suitable for SPPS, is described in six steps with good yields starting from the corresponding α-aminoacids. The coupling reaction assays performed in liquid phase between Nα-Z-hydrazinoesters and N-Fmoc-α-aminoacids demonstrated the low reactivity of the hydrazinoester derivatives. However, we found that the acid fluoride method allowed the formation of hydrazinodipeptides almost quantitatively.

A new synthetic route to protected α-hydrazinoesters in high optical purity using the mitsunobu protocol

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