339241-95-1Relevant academic research and scientific papers
Library design, synthesis and biological exploration of novel 3,4′-bicarbostyril derivatives as potent antimicrobial, antitubercular and antimalarial agents
Jardosh, Hardik H.,Vala, Nileshkumar D.,Patel, Manish P.
, p. 881 - 899 (2017)
Abstract: A library comprises diversely substituted novel 3,4′-bicarbostyril derivatives have been designed by molecular hybridization technique and synthesized via multi-component reaction. Compounds G22 (MIC = 12.5 μg/mL) and G38 (MIC = 25 μg/mL) exhibited 99% inhibition against Mycobacterium tuberculosis, while compounds G40 (IC50 = 0.019 μg/mL) and G20 (IC50 = 0.028 μg/mL) found to have excellent activity against Plasmodium falciparum. Compounds G37 (MIC = 25 μg/mL) and G8, G18, and G38 (MIC = 50 μg/mL) elicited excellent antimicrobial activity compared to standard drugs. Biological results revealed that the potency of the title compounds strongly depends on the length and flexibility of various spacers at N?1, the electronic influence of substituent at R1 and lipophilicity of CH3 group at R2 position on bicarbostyril system. Graphical Abstract: [InlineMediaObject not available: see fulltext.]
Microwave-irradiated synthesis of 1,2-dihydropyridines from n-functionalized enaminones and enals through domino condensation and 6π-azaelectrocyclization
Shaban, Elkhabiry,Hossain, Md. Imran,Wu, Ming-Yu,Takemasa, Yoshihiko,Nagae, Sachie,Peng, Wei,Kawafuchi, Hiroyuki,Inokuchi, Tsutomu
, p. 171 - 182 (2014/02/14)
N-Amino-substituted 1,2-dihydropyridine motifs are constructed using cyclohexane-1,3-diones via the Knoevenagel condensation with enals followed by 6π-electrocyclization using ethylenediammonium diacetate as a catalyst under MW irradiation. A survey of su
