339267-17-3Relevant articles and documents
BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS
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Paragraph 000390, (2020/05/15)
Pharmaceutical compositions of the invention comprise functionalized benzamide derivatives useful as cyclic GMP-AMP synthase- Stimulator of interferon gene (cGAS-STING) pathway agonists, and useful for treating viral diseases and boost antitumor immunity.
Synthesis of trisphaeridine and norchelerythrine through palladium-catalyzed aryl-aryl coupling reactions
Harayama, Takashi,Akamatsu, Hisashi,Okamura, Kana,Miyagoe, Taeko,Akiyama, Toshihiko,Abe, Hitoshi,Takeuchi, Yasuo
, p. 523 - 528 (2007/10/03)
The synthesis of triphaeridine and norchelerythrine through palladium-catalyzed aryl-aryl coupling reactions was studied. The secondary amides were synthesized from 6-bromopiperonylicacid and aniline, and from piperonylic acid and 2-iodoaniline respectively, and were methoxymethylated for the preparation of starting materials for the cyclization reaction. All experiments were carried out in an argon atmosphere and the extract was washed with brine. The nuclear magnetic resonance (NMR) spectral data showed the presence of singlet signals due to aromatic proton in the products.