339274-34-9

Usage

Uses

Used in Pharmaceutical Industry:
(2S)-2-AMINO-2-(2-BROMOPHENYL)ACETIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and medical treatments.
Used in Organic Chemistry Research:
(2S)-2-AMINO-2-(2-BROMOPHENYL)ACETIC ACID is utilized as a versatile compound in organic chemistry research, where its properties and reactivity are harnessed to explore new chemical reactions and mechanisms.
Used in Drug Discovery:
(2S)-2-AMINO-2-(2-BROMOPHENYL)ACETIC ACID is employed as a component in drug discovery processes, leveraging its structural attributes to identify potential therapeutic agents and advance the field of medicinal chemistry.

Upstream product

• 854847-14-6 (2-bromophenyl)malonic acid 
• 773837-37-9 sodium cyanide 
• 6630-33-7 ortho-bromobenzaldehyde 
• 1204705-03-2 (S)-2-(benzylamino)-2-(2-bromophenyl)acetonitrile 
• 1015198-51-2 (R)-N-(2-bromobenzyliden)-N-(tert-butanesulfinyl)amine 
• 1609692-20-7 (R,R_S)-N-[(2-bromophenyl)(cyano)methyl]-2-methylpropane-2-sulfinamide 
• 26767-16-8 2-(2-bromophenyl)-2-oxoacetic acid 
• 2039-88-5 2-bromostyrene 
• 78024-77-8 diethyl (2-bromophenyl)malonate 
• 2178-24-7 ethyl 2-(2-bromophenyl)ethanoate 
• 2835-06-5 phenylglycin 
• 339274-29-2 (R)-2,2,2-trichloro-1-(2-bromophenyl)ethanol 
• 339274-26-9 1-(2-bromophenyl)-2,2,2-trichloroethan-1-one 
• 339274-25-8 (+/-)-2,2,2-trichloro-1-(2-bromophenyl)ethanol 

Relevant academic research and scientific papers

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

Stereochemical aspects and the synthetic scope of the SHi at the sulfur atom. Preparation of enantiopure 3-substituted 2,3-dihydro-1,2- benzoisothiazole 1-oxides and 1,1-dioxides

Intramolecular homolytic substitution (SHi) on the sulfur atom at acyclic N-(o-bromobenzyl)sulfinamides takes place with a complete inversion of the configuration and provides an excellent tool to connect N-tert-butanesulfinylimines with enantiopure 3-substituted benzo-fused sulfinamides (1,2-benzoisothiazoline 1-oxides) and the related pharmacologically relevant sulfonamides. the Partner Organisations 2014.

Efficient access to (1H)-isoindolin-1-one-3-carboxylic acid derivatives by orthopalladation and carbonylation of methyl arylglycinate substrates

The orthopalladation of methyl arylglycinate derivatives has been studied. The reaction proceeds efficiently for different electron-withdrawing and electron-releasing substituents at the aryl ring. The carbonylation of the orthopalladated complexes affords, in a single step, substituted (1H)-isoindolin-1-one-3-carboxylates. These compounds constitute valuable synthetic intermediates and can be transformed diastereoselectively into octahydroisoindole-1-carboxylic acid derivatives, an important scaffold in the synthesis of many biologically active compounds.

A remarkable titanium-catalyzed asymmetric strecker reaction using hydrogen cyanide at room temperature

Close to perfect enantioselectivity (up to 98% ee) is obtained for the formation of amino nitrites using hydrogen cyanide (HCN) as the cyanide source at room temperature for the first time. In an operationally simple process, the catalyst generated from a partially hydrolyzed titanium alkoxide (PHTA) and (S)-N-salicyl-ss-amino alcohol ligand, catalyzes the cyanation of imines in a short reaction time.

Highly enantioselective titanium-catalyzed cyanation of imines at room temperature

(Figure presented) A highly active and enantioselective titanium-catalyzed cyanatlon of imines at room temperature Is described. The catalyst used Is a partially hydrolyzed titanium alkoxide (PHTA) precatalyst together with a readily available N-salicyl-β-aminoalcohol ligand. Up to 98% ee was obtained with quantitative yields In 15 min of reaction time using 5 mol % of the catalyst. Various N-protecting groups such as benzyl, benzhydryl, Boc, and PMP are tolerated.

UREAS AS FACTOR XA INHIBITORS

The present invention is directed to compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

Chemistry of unprotected amino acids in aqueous solution: Direct bromination of aromatic amino acids with bromoisocyanuric acid sodium salt under strong acidic condition

Brominations of unprotected aromatic amino acids such as phenylalanine, tyrosine, and glycine, with bromoisocyanuric acid mono sodium salt (BICA-Na) were conducted in 60% aq. H2SO4 at 0°C to give a mixture of mono-brominated products in good yield. Unexpectedly, meta-bromophenylglycine was obtained as main product accompanied by ortho- and para-substituted products, while phenylalanine gave only ortho- and para-substituted products. Bromination of 2-phenylethylamine or benzylamine showed a tendency similar to the corresponding amino acids.

A practical asymmetric synthesis of homochiral α-arylglycines

Enantioselective reduction of a series of substituted aryl trichloromethyl ketones with the CBS-catecholborane reagent afforded homochiral aryl trichloromethyl carbinols which have been elaborated to give homochiral α-arylglycines in high e.e.