3393-18-8

Usage

Uses

Used in Pharmaceutical Industry:
2'-deoxyinosine 5'-monophosphate is used as an active pharmaceutical ingredient for the development of antiviral and anticancer drugs. Its unique structure allows it to interfere with the replication and transcription processes of certain viruses and cancer cells, making it a potential therapeutic agent.
Used in Research and Development:
In the field of research, 2'-deoxyinosine 5'-monophosphate serves as an essential tool for studying the mechanisms of DNA and RNA synthesis, as well as the regulation of gene expression. It can be used in the synthesis of various nucleic acid analogs and modified oligonucleotides for experimental purposes.
Used in Diagnostics:
2'-deoxyinosine 5'-monophosphate can be employed in the development of diagnostic tools and assays for the detection and monitoring of viral and cancer-related diseases. Its incorporation into molecular probes and detection systems can enhance the sensitivity and specificity of these diagnostic methods.
Used in Drug Delivery Systems:
Similar to gallotannin, 2'-deoxyinosine 5'-monophosphate can be incorporated into novel drug delivery systems to improve its bioavailability, delivery, and therapeutic outcomes. These systems can include organic and metallic nanoparticles, liposomes, and other advanced carriers designed to protect the nucleotide and enhance its efficacy against target cells.

Upstream product

• 890-38-0 2-deoxyinosine 

Relevant academic research and scientific papers

Fully automated continuous meso-flow synthesis of 5′-nucleotides and deoxynucleotides

The first continuous meso-flow synthesis of natural and non-natural 5′-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.

Immobilized Drosophila melanogaster deoxyribonucleoside kinase (DmdNK) as a high performing biocatalyst for the synthesis of purine arabinonucleotides

Fruit fly (Drosophila melanogaster) deoxyribonucleoside kinase (DmdNK; EC: 2.7.1.145) was characterized for its substrate specificity towards natural and non-natural nucleosides, confirming its potential in the enzymatic synthesis of modified nucleotides. DmdNK was adsorbed on a solid ion exchange support (bearing primary amino groups) achieving an expressed activity >98%. Upon cross-linking with aldehyde dextran, expressed activity was 30-40%. Both biocatalysts (adsorbed or cross-linked) were stable at pH 10 and room temperature for 24 h (about 70% of retained activity). The cross-linked DmdNK preparation was used for the preparative synthesis of arabinosyladenine monophosphate (araA-MP) and fludarabine monophosphate (FaraAMP). Upon optimization of the reaction conditions (50 mM ammonium acetate, substrate/ATP ratio= 1:1.25, 2 mM MgCl2, 378C, pH 8) immobilized DmdNK afforded the title nucleotides with high conversion (>90%), whereas with the soluble enzyme lower conversions were achieved (78-87%). Arabinosyladenine monophosphate was isolated in 95% yield and high purity (96.5%).