339301-73-4Relevant academic research and scientific papers
Cyclohexylamine derivatives as subtype selective N-methyl-D-aspartate antagonists
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Page 45, (2010/11/30)
Described are cyclohexylamine derivatives of Formula I Formula VI andFormula VIa and pharmaceutically acceptable salts thereof, wherein R1, g, *, R, V, B, E, Y, G, H, X1, and d are as defined in the description. The compounds of Formulas I and VI are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, stroke, cerebral ischemia, trauma, hypoglycemia, anxiety, migraine headache, convulsions, Parkinson's disease, aminoglycoside antibiotics-induced hearing loss, psychosis, glaucoma, CMV retinitis, opioid tolerance or withdrawal, chronic pain, or urinary incontinence.
Polymer-aided stereodivergent synthesis (PASS): A new concept for the discrete preparation of optical antipodes
Ten Holte, Peter,Thijs, Lambertus,Zwanenburg, Binne
, p. 1093 - 1095 (2007/10/03)
A new concept to the discrete prepartion of optical antipodes is reported. The approach makes use of a cyclization/cleavage procedure that has been applied to polymer-supported quasi-meso compound 1, containing a polymeric leaving group and a regular leaving group. Two-directional cyclization leads to the formation and separation of quasi-enantiomers 2 and 3 simultaneously, with one being immobilized and on free in solution. Treatment of 2 and 3 with appropriate nucleophiles gives discrete enantiomers 4 and 5.
