339309-53-4Relevant academic research and scientific papers
Design, syntheses, and structure-activity relationships of indan derivatives as endothelin antagonists; new lead generation of non-peptidic antagonist from peptidic leads
Morimoto, Hiroshi,Fukushima, Chiaki,Yamauchi, Rikako,Hosino, Tomoko,Kikkawa, Kohei,Yasuda, Kosuke,Yamada, Koichiro
, p. 255 - 268 (2007/10/03)
A new lead generation of non-peptidic ETA antagonists from two peptidic ETA-selective ones, BQ-123 and FR139317, was performed. Using computer assisted molecular modeling, a putative pharmacophore was constructed from the superpositi
