339315-26-3

Basic information

• Product Name: 2-benzyl-2-{[2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-N,N-dimethylpropanamide
• CAS NO: 339315-26-3
• Molecular Weight: 476.616
• Mol File: 339315-26-3.mol

Chemical Properties

• CAS DataBase Reference: 2-benzyl-2-{[2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-N,N-dimethylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-2-{[2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-N,N-dimethylpropanamide(339315-26-3)
• EPA Substance Registry System: 2-benzyl-2-{[2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-N,N-dimethylpropanamide(339315-26-3)

Safety Data

• Hazardous Substances Data: 339315-26-3(Hazardous Substances Data)

Upstream product

• 339315-20-7 2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide 
• 339315-16-1 3-hydroxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide 
• 339315-18-3 2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methylpropanoic acid 
• 4835-90-9 3-Hydroxy-2,2-dimethylpropanoic acid 

Downstream Products

• 339315-35-4 2-[(2-benzyl-2-({2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl}amino)-1-oxopropyl)amino]-2,N,N-trimethylpropanamide 

Relevant articles and documents

Synthesis of conformationally restricted cyclic pentadepsipeptides via direct amide cyclization

The 2,2-disubstituted 2H-azirin-3-amines 6 (3-amino-2H-azirines) were used as building blocks for α,α-disubstituted α-amino acids in the preparation of 16-membered cyclic depsipeptides 14. The linear precursors containing four α,α-disubstituted α-amino acids, the pentapeptides 13, were synthesized starting with β-hydroxy acids 5 via the 'azirine/oxazolone method'. The cyclic depsipeptides 14 were formed via 'direct amide cyclization' and the influence of several factors on this cyclization was investigated in the following way: (a) using the same composition of α,α-disubstituted α-amino acids, but changing their respective positions in the peptide chain; (b) using different C-terminal α,α-disubstituted α-amino acids in the peptide chain; (c) using different β-hydroxy acids; and (d) using different diastereoisomers of the peptides.