339317-40-7Relevant academic research and scientific papers
Lipid A structures containing novel lipid moieties: Synthesis and adjuvant properties
Jiang, Zi-Hua,Bach, Mimi V,Budzynski, Wladyslaw A,Krantz, Mark J,Koganty,Longenecker
, p. 2193 - 2196 (2002)
Structurally well-defined immune stimulatory molecules are important components of new generation molecular vaccines. In this paper, the design and synthesis of two lipid A analogues containing an unnatural tri-lipid acyl group are described. In a totally synthetic liposomal vaccine system, these re-designed lipid A analogues demonstrate potent immune stimulatory properties including antigen specific T-cell activation.
