339339-19-4

Usage

Molecular structure

Contains a hexahydroquinoline ring system with a cyano group attached to the third carbon.

Functional groups

Amino group at the second carbon, methyl group at the first carbon, nitrophenyl group at the fourth carbon, and a cyano group at the third carbon.

Potential applications

Pharmaceuticals or material science due to its unique structure and potential reactivity.

Health and environmental risks

May pose certain risks, further studies may be needed to fully understand its properties and potential uses.

Upstream product

• 36646-78-3 3-(p-tolylamino)-5,5-dimethylcyclohex-2-enone 
• 99-61-6 3-nitro-benzaldehyde 
• 109-77-3 malononitrile 
• 126-81-8 dimedone 
• 106-49-0 p-toluidine 

Relevant academic research and scientific papers

Hexamethylenetetramine-based ionic liquid anchored onto the metal–organic framework MIL-101(Cr) as a superior and reusable heterogeneous catalyst for the preparation of hexahydroquinolines

Regarding the significance of medicinal and pharmacological sciences, we explored one-pot multicomponent reaction of aromatic aldehydes, aryl amines, malononitrile and dimedone in the presence of HMTA-BAIL@MIL-101 (Cr) as a novel, stable and strong catalyst. The remarkable features of this approach are good to excellent yields (92–98%), short reaction times (10–20?min), low catalyst loading, reusability and stability of the catalyst. The prepared hexamethylenetetramine-based ionic liquid/MIL-101(Cr) composite was identified via FE-SEM, XRD, EDS, TGA, BET and FT-IR techniques.

Eco-friendly and ingenious multicomponent synthesis of N-arylquinolines using DABCO/TEAB in water

An easy, improved, and environmentally benign synthesis of N-arylquinolines is reported via one-pot multicomponent reaction of aromatic aldehydes, active methylene compounds and 3-arylamino-5,5-dimethylcyclohex-2-enone utilizing catalytic amount of combin

Study of the catalytic activity of Zr(HPO4)2 in the synthesis of hexahydroquinoline derivatives under solvent-free conditions

2-Amino-7,7-dimethyl-5-oxo-1,4-diaryl-1,4,5,6,7,8-hexahydroquinoline-3- carbonitrile derivatives were synthesized by the one-pot four-component reaction of aromatic aldehydes, malononitrile, dimedone and arylamines in the presence of Zr(HPO4)s

DBU-catalyzed expeditious and facile multicomponent synthesis of N-arylquinolines under microwave irradiation

N-Arylquinoline derivatives are obtained in excellent yields by a rapid, easy, and efficient one-pot multicomponent reaction of aromatic aldehydes, 3-arylamino-5,5-dimethylcyclohex-2-enone, and active methylene compounds utilizing 1,8-diazabicyclo[5.4.0]u

Three-component green synthesis of N-arylquinoline derivatives in ionic liquid [Bmim+][BF4-]: reactions of arylaldehyde, 3-arylamino-5,5-dimethylcyclohex-2-enone, and active methylene compounds

Three series of N-arylquinoline derivatives were synthesized by the three-component reactions of arylaldehyde, 3-arylamino-5,5-dimethylcyclohex-2-enone, and active methylene compounds including malononitrile, meldrum's acid, and 1,3-indenedione in ionic l