33948-97-9

Upstream product

• 120-72-9 indole 
• 779-84-0 N-phenylsalicylaldimine 
• 89-95-2 2-methyl-benzyl alcohol 
• 90-02-8 salicylaldehyde 
• 135-02-4 ortho-anisaldehyde 
• 614-65-3 2-hydroxybenzaldehyde phenylhydrazone 
• 126-81-8 dimedone 
• 109-77-3 malononitrile 

Downstream Products

• 1426131-52-3 C₄₈H₈₀O₄₀*C₂₃H₁₈N₂O 
• 1426131-50-1 C₃₆H₆₀O₃₀*C₂₃H₁₈N₂O 
• 1426131-51-2 C₄₂H₇₀O₃₅*C₂₃H₁₈N₂O 
• 120-72-9 indole 

Relevant academic research and scientific papers

Trimethylsilyl iodide as a multifunctional agent in the one-pot synthesis of 9-(1 H -Indol-3-yl)xanthen-4-(9 H)-ones from O -methyl protected salicylaldehydes, indoles, and β-dicarbonyl compounds

Trimethylsilyl iodide (TMSI) is introduced as an efficient reagent for the one-pot synthesis of 9-(1H-indol-3-yl)xanthen-4-(9H)-ones using the reaction of 2-methoxybenzaldehydes (as O-methyl protected salicylaldehydes), indoles, and β-dicarbonyl compounds. In this protocol, a set of TMSI reactions involving silylation, silyl enol ether formation, methyl deprotection, and nucleophilic substitution/cyclization are performed to furnish the target product. The key step in this protocol is the deprotection of the methoxy group by TMSI. Georg Thieme Verlag Stuttgart, New York.

Facile construction of 3-indolochromenes and 3-indoloxanthenes via EDDF catalyzed one-pot three component reactions

A novel and green strategy for the construction of biologically relevant 3-indolochromene and 3-indoloxanthene scaffolds is reported using EDDF as a catalyst and ethylene glycol as a promoter solvent. The catalytic system offers wider applicability, crossing over a variety of substrates, besides affording exclusively the desired product in shorter reaction times and high yields. Furthermore, the ease of work-up and purification combined with the recyclability of the EDDF-ethylene glycol system makes the present method environmentally sustainable and amenable to large-scale synthesis as well.

Synthesis of bis(indolyl)methanes catalyzed by triethylborane

Triethylborane (TEB) was found to be a mild, efficient, and acid catalyst in electrophilic substitution reaction of indoles with aldehydes compounds to afford the corresponding bis(indolyl)methanes. Vibrindole A (5) and bis(indolyl)methanes derivatives 16

Preparation of G-CuO NPs and G-ZnO NPs with mallow leaves, investigation of their antibacterial behavior and synthesis of bis(indolyl)methane compounds under solvent-free microwave assisted dry milling conditions using G-CuO NPs as a catalyst

In this study, biogenic copper and zinc oxide nanoparticles (G-ZnONPs and G-CuONPs) were synthesized by the green synthesis method using Malva parviflora L. (Millow) leaf extract and the obtained nanoparticles were characterized in detail with UV-Vis, FTIR, SEM, XRD. The antibacterial properties of the synthesized nanoparticles on gram-positive and gram-negative bacteria were investigated and it was found that the nanoparticles had high antimicrobial activity in the results of the experiments. With the obtained G-CuONPs, the synthesis of bis(indolyl)methanes with the "green" one-pot synthesis using microwave was achieved quickly and with high efficiency, and the thermal behavior of the obtained products was investigated.

Optimization of novel oxidative DIMs as Nur77 modulators of the Nur77-Bcl-2 apoptotic pathway

Nur77, an orphan nuclear receptor, is a member of the nuclear receptor superfamily. Nur77 plays important roles in various biological processes. Previously we reported that BI1071(DIM-C-pPhCF3+MeSO3-), an oxidiz

Water-mediated green and efficient synthesis of bis(Indolyl)methanes using ammonium iron(II) sulfate

An efficient protocol for the synthesis of symmetrical 3,3’-bis(indolyl)arylmethanes catalyzed by green and easily available ammonium iron(II) sulfate (Mohr’s salt) has been developed in “green” water solvent afforded in excellent yield.

Catalytic efficiency of β-cyclodextrin hydrate-chemoselective reaction of indoles with aldehydes in aqueous medium

The catalytic efficiency of β-cyclodextrin hydrate has been investigated towards the eco-compatible synthesis of bis-(indolyl)methanes in aqueous medium by the chemoselective reaction of indoles with differently substituted aryl and alkyl aldehydes under

Air-stable μ-oxo-bridged binuclear titanium(IV) salophen perfluorooctanesulfonate as a highly efficient and recyclable catalyst for the synthesis of bis(indolyl) methane derivatives

An air-stable μ-oxo-bridged binuclear Lewis acid of titanium(IV) salophen perfluorooctanesulfonate [{Ti(salophen)H2O}2O][OSO2C8F17]2 (1) was successfully synthesized by the reaction of TiIV(salophen)Cl2 with AgOSO2C8F17 and characterized by different techniques such as IR, NMR and HRMS. TG-DSC analysis showed that this complex was thermally stable at 220 °C. Meanwhile, it exhibited good solubility in polar organic solvents and good ionic dissociation in CH3CN solution. Fluorescence spectra and Hammett indicator results indicated that the complex had relatively strong acidity. And it showed high catalytic efficiency for the synthesis of bis(indolyl) methane derivatives through Friedel-crafts reaction of aldehyde/ketone with indoles. Moreover, it can be reused five times with minimal changes in catalytic efficiency.

3-Amino-5-mercapto-1,2,4-triazole-functionalized Fe3O4 magnetic nanocomposite as a green and efficient catalyst for synthesis of bis(indolyl)methane derivatives

A core–shell Fe3O4?silica magnetic nanocomposite functionalized with 3-amino-5-mercapto-1,2,4-triazole (Fe3O4/SiO2/PTS/AMTA) was prepared using Fe3O4 with silica layer, and its s

COMPOUNDS AND USES THEREOF

A pharmaceutical composition is described herein, including an antimicrobial agent and a compound having Formula A, or Formula B. Methods of using the pharmaceutical compositions to treat microbial infection are also described.