33950-71-9

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 15, p. 1535, 1978 DOI: 10.1002/jhet.5570150866

Upstream product

• 136131-48-1 2-(ethoxycarbonyl)-1,4-dihydro-1,4-epoxynaphthalene 
• 7605-30-3 ethyl 2-phenylsulfonylacetate 
• 292638-85-8 acrylic acid methyl ester 
• 3007-91-8 ethyl-2-naphthoate 

Downstream Products

• 98621-40-0 1-hydroxy-4-phenylazo-[2]naphthoic acid ethyl ester 
• 54379-93-0 1-Hydroxy-4-(4-methoxy-phenylazo)-naphthalene-2-carboxylic acid ethyl ester 
• 98621-41-1 4-(4-Diethylamino-phenylazo)-1-hydroxy-naphthalene-2-carboxylic acid ethyl ester 
• 7732-44-7 1-hydroxynaphthalene-2-carbohydrazide 
• 331282-15-6 1-benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester 
• 331282-27-0 1-benzyloxy-4-[2-(8-oxo-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester 
• 1027575-72-9 1-benzyloxy-4-(2-bromo-ethyl)-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group

An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.

A novel multicomponent reaction of arynes, β-keto sulfones, and Michael-type acceptors: A direct synthesis of polysubstituted naphthols and naphthalenes

(Chemical Equation Presented) A novel multicomponent reaction of arynes, β-keto sulfones, and Michael-type acceptors is presented, providing an efficient method for the synthesis of polysubstituted naphthols and polysubstituted naphthalenes. Further investigation suggests that the tandem reaction may proceed via a sequential nucleophilic attack to arynes, intramolecular nucleophilic substitution followed by a Michael addition, and a ring closure - elimination process.