339530-93-7Relevant academic research and scientific papers
Syntheses of enantiomerically pure (R)- and (S)-bicalutamide
James, Kenneth D,Ekwuribe, Nnochiri N
, p. 5905 - 5908 (2002)
The racemic antiandrogen bicalutamide is the leading antiandrogen used for the treatment of prostate cancer. The (R)-isomer possesses virtually all of the activity, but both isomers are metabolized by the liver. A convenient synthetic route to the active enantiomer would be an attractive option for patients who are hepatically impaired. We now demonstrate a rather short synthesis of (R)-bicalutamide, starting with a naturally occurring, chiral precursor.
