339589-34-3Relevant academic research and scientific papers
Branched adamantyl and noradamantyl aryl-and aralkylpiperazines with serotonin 5-HT 1A activity
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Page 4-5, (2008/06/13)
This invention provides compounds and methods using them to provide neuroprotection and prevent or limit processes of neurodegeneration in mammals, including Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, AIDS dementia, retinal disease, d
Synthesis and SAR of adatanserin: Novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT2 activity as potential anxiolytic and antidepressant agents
Abou-Gharbia, Magid A.,Childers Jr., Wayne E.,Fletcher, Horace,McGaughey, Georgia,Patel, Usha,Webb, Michael B.,Yardley, John,Andree, Terrance,Boast, Carl,Kucharik Jr., Robert J.,Marquis, Karen,Morris, Herman,Scerni, Rosemary,Moyer, John A.
, p. 5077 - 5094 (2007/10/03)
Several novel functionalized adamantyl aryl- and heteroarylpiperazine derivatives were prepared and examined in various receptor binding and behavioral tests to determine their serotonin receptor activities. Many compounds demonstrated modest to high affi
