3396-73-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Deoxy-D-erythro-pentose is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-deoxy-D-erythro-pentose serves as a valuable building block for creating complex organic molecules. Its versatility in reactions makes it a useful component in the synthesis of a wide range of chemical products.
Used in Research and Development:
3-Deoxy-D-erythro-pentose is utilized in research and development for studying the structure and function of sugars and their role in biological systems. Its unique properties make it an interesting subject for scientific investigation, potentially leading to new discoveries and applications.

Upstream product

• 51785-69-4 methyl 3-deoxy-β-D-erythro-pentopyranoside 
• 4860-82-6 2,3-anhydro-α-D-ribofuranoside de methyle 
• 4395-36-2 methyl β-D-erythro-3-deoxy-pentofuranoside 
• 104085-32-7 1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)but-3-en-2-ol 
• 3150-13-8 (1R,2R,5R,6R)-2-Methoxy-3,7-dioxa-bicyclo[4.1.0]heptan-5-ol 
• 40147-20-4 methyl-[O²-(toluene-4-sulfonyl)-β-D-arabinopyranoside] 
• 79549-20-5 methyl-3,4-O-isopropylidene-2-O-tosyl-β-D-arabinopyranoside 
• 73-03-0 cordycepin 

Downstream Products

• 98309-06-9 (S)-4,5-dihydroxy-2-(4-nitro-phenylhydrazono)-valeraldehyde-(4-nitro-phenylhydrazone) 
• 15386-69-3 (2R,3R,5S)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolan-3-ol 
• 73-03-0 cordycepin 

Relevant academic research and scientific papers

STEREOCHEMISTRY OF THE 1,2-WITTIG REARRENGEMENT: A SYNTHESIS OF SYN-1,3-DIOL MONOETHERS

The Wittig rearrangement of β-alkoxyalkyl allyl ethers has been studied and found to provide syn-1,3-diol derivatives in 14-32percent yield and with useful levels of diastereoselection.

The Chemoenzymatic Synthesis of 2-Chloro- and 2-Fluorocordycepins

Two approaches to the chemoenzymatic synthesis of 2-fluorocordycepin and 2-chlorocordycepin were studied: (i) the use of 3′-deoxyadenosine (cordycepin) and 3′-deoxyinosine (3′dIno) as donors of 3-deoxy- d -ribofuranose in the transglycosylation of 2-fluoro- (2F Ade) and 2-chloroadenine (2Cl Ade) catalyzed by the recombinant E. coli purine nucleoside phosphorylase (PNP), and (ii) the use of 2-fluoroadenosine and 3′-deoxyinosine as substrates of the cross-glycosylation and PNP as a biocatalyst. An efficient method for 3′-deoxyinosine synthesis starting from inosine was developed. However, the very poor solubility of 2Cl Ade and 2F Ade is the limiting factor of the first approach. The second approach enables this problem to be overcome and it appears to be advantageous over the former approach from the viewpoint of practical synthesis of the title nucleosides. The 3-deoxy-α- d -ribofuranose-1-phosphate intermediary formed in the 3′dIno phosphorolysis by PNP was found to be the weak and marginal substrate of E. coli thymidine (TP) and uridine (UP) phosphorylases, respectively. Finally, one-pot cascade transformation of 3-deoxy- d -ribose in cordycepin in the presence of adenine and E. coli ribokinase, phosphopentomutase, and PNP was tested and cordycepin formation in ca. 3.4% yield was proved.