33977-11-6

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-2-methoxy-benzoic acid hydrazide is used as a building block for the synthesis of heterocyclic compounds with potential biological activity, contributing to the development of new pharmaceuticals.
Used in Organic Synthesis:
As a reagent, 5-Chloro-2-methoxy-benzoic acid hydrazide is used to introduce its specific moiety into target molecules, facilitating the creation of new organic compounds with desired properties.
Used in Drug Discovery and Development:
5-Chloro-2-methoxy-benzoic acid hydrazide is utilized for its potential anti-inflammatory, anti-cancer, and antimicrobial properties, making it a key component in the search for new therapeutic agents.
Used in Medicinal Chemistry Research:
5-Chloro-2-methoxy-benzoic acid hydrazide is a subject of ongoing research in medicinal chemistry, where its potential therapeutic applications are being explored to enhance understanding and treatment options for various diseases and conditions.

InChI:InChI=1/C8H9ClN2O2/c1-13-7-3-2-5(9)4-6(7)8(12)11-10/h2-4H,10H2,1H3,(H,11,12)

Upstream product

• 33924-48-0 methyl 5-chloro-2-methoxybenzoate 
• 3438-16-2 5-chloro-2-methoxybenzoic acid 
• 68216-06-8 ethyl 5-chloro-2-methoxybenzoate 

Downstream Products

• 128772-81-6 5-(5-Chloro-2-methoxy-phenyl)-3H-[1,3,4]oxadiazol-2-one 
• 901449-59-0 N-(2-methoxy-5-chlorobenzamido)-N'-phenylthiourea 
• 1287116-19-1 4-(2-(5-chloro-2-methoxyphenyl)carbohydrazide)benzoic acid methyl ester 
• 1424272-37-6 4-(5-(5-chloro-2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)benzoic acid methyl ester 
• 1424272-39-8 methyl 4-(5-(5-chloro-2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzoate 
• 133344-95-3 5-Chloro-2-methoxy-benzoic acid N',N'-bis-(2-cyano-ethyl)-hydrazide 
• 133344-91-9 5-Chloro-2-methoxy-benzoic acid N'-(2-cyano-ethyl)-hydrazide 
• 133345-09-2 3-[5-(5-Chloro-2-methoxy-phenyl)-2-thioxo-[1,3,4]oxadiazol-3-yl]-propionitrile 

Relevant academic research and scientific papers

Complex, its preparation method, fluorinion sensor and method for detecting fluorinion

The invention provides a complex as shown in a chemical formula 1 in the specification, a preparation method of the complex, a fluorine ion sensor and a method for detecting a fluorine ion. In the chemical formula 1, m is an integer from 0 to 5, n is an integer from 0 to 4, R1, R2 and R3 are independently selected from a group composed of deuterium, tritium, halogen, a cyano group, an amino group, nitryl, hydroxyl, carboxyl, substituted or unsubstituted C2-C30 ether groups, substituted or unsubstituted C2-C30 ester groups, substituted or unsubstituted C1-C30 alkyls, substituted or unsubstituted C2-C30 alkenyls, substituted or unsubstituted C2-C30 alkynyls, substituted or unsubstituted C3-C30 cycloalkyls, substituted or unsubstituted C1-C30 alkoxyl groups, substituted or unsubstituted C3-C30 cycloalkoxyls, substituted or unsubstituted C5-C30 aryls, substituted or unsubstituted C5-C30 aryloxys and substituted or unsubstituted C3-C30 heteroaryls.

Compound, preparation method thereof, fluorinion sensor and method for detecting fluorinion

The invention provides a compound disclosed as chemical formula 1 and a preparation method thereof, a fluoride ion sensor and a fluorine ion detection method. In the chemical formula 1, m is a whole number ranging from 0 to 5, n is a whole number ranging from 0 to 4, and R1 and R2 are respectively independently selected from deuterium, tritium, halogen, cyano gorup, amino group, nitro group, hydroxy group, carboxyl group, substituted or unsubstituted C2-C30 ether group, substituted or unsubstituted C2-C30 ester group, substituted or unsubstituted C1-C30 alkyl group, substituted or unsubstituted C2-C30 alkenyl group, substituted or unsubstituted C2-C30 alkynyl group, substituted or unsubstituted C3-C30 cycloalkyl group, substituted or unsubstituted C1-C30 alkoxy group, substituted or unsubstituted C3-C30 cycloalkoxy group, substituted or unsubstituted C5-C30 aryl group, substituted or unsubstituted C5-C30 aryloxy group and substituted or unsubstituted C3-C30 heteroaryl group.

CRYOPYRIN INHIBITORS FOR PREVENTING AND TREATING INFLAMMATION

Inhibitors that are anti-inflammatory agents are provided, as are methods of using the analogs to inhibit inflammation and prevent or treat diseases and conditions associated with inflammation, such as heart failure and autoimmune diseases.

Anion binding of N-(o-Methoxybenzamido)thioureas: Contribution of the intramolecular hydrogen bond in the N-benzamide moiety

N-(o-Methoxybenzamido)- thioureas (2X/2Y) are found to show an enhanced anion binding affinity with binding constants over 107 mol -1L orders of magnitude for AcO- and a redshifted absorption of the anion binding complexes in acetonitrile (MeCN) relative to those of N-benzamidothioureas (1) that bear no o- OMe in the N-benzamide moiety, despite the electron-donating character of o-OMe. Absorption of the anion-2X/ 2Y complex was shown to be of the same charge-transfer nature as that of the anion-1 complex, but its dependence on substituent X is interestingly influenced by the o-MeO···HNC=O six-membered-ring intramolecular hydrogen bond identified in 2X/2Y. Such an intramolecular hydrogen bond is suggested to be responsible for the enhanced anion binding affinity. In the presence of this intramolecular hydrogen bond, the anion binding constant of 2X was found to be independent of substituent X at the N-phenyl ring, as in the case of 1, whereas that of 2Y showed an amplified dependence on substituent Y at the N′-phenyl ring, but to a lower extent than that of 1. A similar ring intramolecular hydrogen bond was purported to exist in 2Za, 2Zd, and 2Ze, which bear NHMe, F, and Cl as the ortho substituent in the N-benzamide moiety. In terms of the current roles of thiourea in not only anion recognition and sensing but also organocatalysis and crystal engineering, the present finding would be of significance for a wider structural diversity of smart thiourea derivatives with predesigned functions.