33982-85-3Relevant articles and documents
A concise synthesis of atipamezole
Wong,Gluchowski
, p. 139 - 140 (1995)
Atipamezole (1), a potent α2 adrenergic receptor antagonist, was synthesized in four steps from dibromide 2 and 2,4-pentanedione.
An unexpected directing effect in the asymmetric transfer hydrogenation of α,α-disubstituted ketones
Soni, Rina,Collinson, John-Michael,Clarkson, Guy C.,Wills, Martin
supporting information; experimental part, p. 4304 - 4307 (2011/10/11)
α,α-Disubstituted ketones containing an aromatic ring or alkene are reduced in high enantiomeric excess using an asymmetric transfer hydrogenation catalyst. The sense of reduction indicates that the unsaturated region of the ketone adopts a position adjacent to the Ru-bound η6-arene ring in the reduction transition state.