33995-30-1Relevant academic research and scientific papers
ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND USES THEREOF
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Page/Page column 46, (2019/11/12)
Disclosed are compounds and pharmaceutically acceptable salts thereof, which are useful as antibacterial agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of the invention. Related methods of treating various infections in mammals, such as bacterial infections, are disclosed. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents
Chacko, Shibin,Boshoff, Helena I. M.,Singh, Vinayak,Ferraris, Davide M.,Gollapalli, Deviprasad R.,Zhang, Minjia,Lawson, Ann P.,Pepi, Michael J.,Joachimiak, Andrzej,Rizzi, Menico,Mizrahi, Valerie,Cuny, Gregory D.,Hedstrom, Lizbeth
, p. 4739 - 4756 (2018/05/23)
New drugs and molecular targets are urgently needed to address the emergence and spread of drug-resistant tuberculosis. Mycobacterium tuberculosis (Mtb) inosine 5′-monophosphate dehydrogenase 2 (MtbIMPDH2) is a promising yet controversial potential target
COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS
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Page/Page column 140; 141, (2014/03/22)
Disclosed are compounds and pharmaceutically acceptable salts thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound selectively inhibits a parasitic IMPDH versus a host IMPDH. Also disclosed are pharmaceutical compositions comprising one or more compounds of the invention. Related methods of treating various parasitic and bacterial infections in mammals are disclosed. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
