33995-37-8

Usage

Classification

Synthetic auxin herbicide

Function

Controls broadleaf weeds in agriculture

Mechanism

Disrupts plant growth and causes uncontrolled cell division, leading to plant death

Environmental persistence

Can persist in soil, water, and air

Environmental and health concerns

Drift damage to non-target crops, water contamination, potential human health risks

Use in agriculture

Commonly used, particularly in genetically modified crops that are resistant to its effects.

Upstream product

• 591-35-5 3,5-dichlorophenol 
• 600-00-0 ethyl 2-bromoisobutyrate 

Relevant academic research and scientific papers

Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers

The systematic discovery of functional fragments binding to the composite interface of protein complexes is a first critical step for the development of orthosteric stabilizers of protein-protein interactions (PPIs). We have previously shown that disulfide trapping successfully yielded covalent stabilizers for the PPI of 14-3-3 with the estrogen receptor ERα. Here we provide an assessment of the composite PPI target pocket and the molecular characteristics of various fragments binding to a specific subpocket. Evaluating structure-activity relationships highlights the basic principles for PPI stabilization by these covalent fragments that engage a relatively large and exposed binding pocket at the protein/peptide interface with a "molecular glue"mode of action.