340011-08-7Relevant academic research and scientific papers
Non-peptidic inhibitors of human chymase. Synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones
Akahoshi, Fumihiko,Ashimori, Atsuyuki,Yoshimura, Takuya,Imada, Teruaki,Nakajima, Masahide,Mitsutomi, Naoko,Kuwahara, Shigeki,Ohtsuka, Tatsuyuki,Fukaya, Chikara,Miyazaki, Mizuo,Nakamura, Norifumi
, p. 301 - 315 (2007/10/03)
Chymase possesses a wide variety of actions, including promotion of angiotensin II production and histamine release from mast cells. However, due to a lack of effective inhibitors featuring both high inhibitory activity and high metabolic stability, the p
